LOC728896 Inhibitors

Wortmannin and Triciribine, by inhibiting PI3K and AKT respectively, can alter the PI3K/AKT signaling pathway, which is integral to cell survival and metabolism. Similarly, Dasatinib targets Src-family tyrosine kinases, which are involved in numerous signaling pathways, thereby potentially affecting the function of proteins that rely on these pathways for activation. Go6976 disrupts Protein kinase C activity, which is pivotal in a multitude of cellular processes, including signal transduction, cell proliferation, and apoptosis. This disruption can influence the activity of proteins associated with these processes. The DNA methyltransferase inhibitor, 5-Azacytidine, can induce DNA hypomethylation, which in turn can lead to altered gene expression and impact protein synthesis.

MG132, as a proteasome inhibitor, can cause an accumulation of proteins within the cell, thus potentially influencing the function of proteins regulated by proteasomal degradation. SB431542 and LY2109761 inhibit TGF-beta receptor signaling, which is important for cellular processes like proliferation and differentiation, thus impacting proteins within this pathway. PD173074 and SU5402 inhibit FGFR and VEGFR tyrosine kinases, respectively, affecting signaling pathways crucial for angiogenesis and cell proliferation, which can alter the activity of related proteins. Y-27632, as a ROCK inhibitor, can have effects on cellular structures like the cytoskeleton, thereby potentially affecting proteins involved in cell motility and structure. Lastly, ZM-447439, an Aurora kinase inhibitor, can disrupt the cell cycle, specifically mitosis, and consequently affect proteins that are crucial for cell division.