LOC647194 Inhibitors

LY294002 inhibits PI3K, thereby reducing AKT phosphorylation and affecting downstream signaling that can impact protein functions associated with survival and proliferation. PD98059 and U0126 are both MEK inhibitors, but U0126 is more selective for MEK1/2, and both compounds disrupt the MAPK/ERK pathway, potentially altering the activity of proteins involved in cell growth and differentiation. SB203580 and SP600125 target different members of the MAP kinase family, namely p38 MAPK and JNK, respectively. These kinases are involved in responses to stress, inflammation, and apoptotic signals, and their inhibition can influence the function of related proteins. PP2 inhibits Src family tyrosine kinases, affecting various signaling pathways that govern processes like cell adhesion and growth, while Y-27632 inhibits the Rho-associated kinase ROCK, which could affect proteins related to cytoskeletal dynamics and cell motility.

MG132 acts as a proteasome inhibitor, which can lead to increased levels of proteins within the cell by preventing their degradation, thereby potentially influencing a multitude of cellular processes. LY83583 inhibits guanylate cyclase, affecting cGMP-dependent pathways and impacting protein functions, while DAPT inhibits γ-secretase, potentially altering Notch pathway signaling, which is involved in cell differentiation. BAPTA-AM serves as a calcium chelator, disrupting calcium signaling, which is crucial for a variety of cellular functions, possibly affecting proteins regulated by these signals. Finally, KN-93 is a CaMKII inhibitor, which modulates calcium/calmodulin-dependent signaling pathways, potentially influencing proteins associated with synaptic plasticity.