LCE1E Inhibitors
LCE1E inhibitors are a set of chemical compounds that diminish the functional activity of the LCE1E protein through modulation of the NF-kB signaling pathway, which is pivotal in the regulation of skin barrier formation and inflammatory responses. Glycyrrhizic acid functions by inhibiting 11β-hydroxysteroid dehydrogenase type 2, leading to increased cortisol levels that in turn inhibit NF-kB, reducing LCE1E expression. Similarly, curcumin suppresses the NF-kB pathway by inhibiting the IKK complex, while resveratrol and sulforaphane directly inhibit NF-kB activation. Quercetin targets upstream PI3K activity, and BAY 11-7082 blocks the phosphorylation of IκBα, both resulting in lowered NF-kB activity and thus LCE1E expression. Epigallocatechin gallate (EGCG) and parthenolide also inhibit NF-kB activation, with SN50 impeding its nuclear translocation and transcriptional function, culminating in a reduction of LCE1E levels, crucial for the epidermal differentiation complex.
These inhibitors, by targeting diverse aspects of the NF-kB pathway, achieve a concerted downregulation of LCE1E. The antioxidant and NF-kB inhibitor Pyrrolidinedithiocarbamic acid ammonium salt, along with ebselen, repress NF-kB activity to lower LCE1E expression. Caffeic acid phenethyl ester (CAPE) exerts its action by attenuating the transcriptional activity of NF-kB, which is essential for the induction of LCE1E. The collective action of these compounds leads to a comprehensive diminution of LCE1E, despite their differing points of interference within the NF-kB signaling cascade. Thus, the inhibition spectrum ranges from the prevention of nuclear translocation of NF-kB by compounds like SN50 to the blockade of upstream signaling events by agents like quercetin and sulforaphane, all converging to suppress LCE1E, a protein integral to skin barrier integrity and inflammatory response regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
Glycyrrhizic acid, a triterpenoid saponin, inhibits 11β-hydroxysteroid dehydrogenase type 2, which in turn increases the level of cortisol. Elevated cortisol inhibits the NF-kB pathway, which is crucial for the expression of late cornified envelope (LCE) proteins such as LCE1E, thus leading to a decrease in LCE1E levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to suppress the NF-kB signaling pathway by inhibiting the IKK complex, thus downregulating the expression of many inflammation-related genes. As LCE1E is also modulated by NF-kB, curcumin would lead to diminished LCE1E expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, is known to inhibit NF-kB activation. Through this action, it could decrease the expression of LCE1E, as the NF-kB pathway is one of the key regulators of genes involved in skin barrier formation, including LCE1E. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, inhibits phosphoinositide 3-kinases (PI3K), which are upstream of NF-kB. By diminishing PI3K activity, quercetin would indirectly suppress NF-kB-mediated transcription of LCE1E. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, an isothiocyanate derived from cruciferous vegetables, is reported to inhibit NF-kB activation. This compound could therefore reduce the expression of LCE1E by modulating the NF-kB pathway activity. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-kB activation by blocking the phosphorylation of IκBα. This inhibition would diminish the expression of genes regulated by NF-kB, like LCE1E. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the major catechin in green tea, is known to inhibit NF-kB activation. By interfering with this pathway, EGCG would decrease the transcriptional activity leading to LCE1E expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a sesquiterpene lactone, inhibits the NF-kB pathway by blocking the IκB kinase complex. This action would lead to decreased expression of LCE1E. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
Pyrrolidinedithiocarbamic acid ammonium salt acts as an antioxidant and NF-kB inhibitor. By reducing NF-kB activity, Pyrrolidinedithiocarbamic acid ammonium salt would subsequently decrease the expression of LCE1E. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is a selenium-containing compound that inhibits NF-kB activation. By doing so, it could lead to diminished expression of LCE1E. | ||||||