LAPTM5 Activators
LAPTM5 Activators encompass a range of chemical compounds that indirectly boost the operational efficiency of LAPTM5 through distinct signaling cascades and cellular processes. Forskolin, by heightening cAMP levels, indirectly fosters LAPTM5's functions, potentially by PKA-mediated phosphorylation, which could influence LAPTM5's role in lysosomal signaling. PMA activates PKC, which may enhance LAPTM5's involvement in protein sorting within lysosomes. Ionomycin's facilitation of intracellular calcium surges could activate calcium-responsive proteins, indirectly impacting LAPTM5's endo-lysosomal operations, while All-trans Retinoic Acid's influence on cellular growth might heighten LAPTM5's role during differentiation. Insulin, through the PI3K/Akt pathway, and 8-Bromo-cAMP, by activating PKA, could both play a role in modulating LAPTM5's lysosomal functions by affecting its localization and stability.
LAPTM5 activators are a diverse array of chemical compounds that indirectly stimulate LAPTM5's functional activity via various signaling pathways and cellular processes, each distinct in its mechanism of action. Forskolin, through the elevation of intracellular cAMP levels, may indirectly facilitate LAPTM5's function by enabling PKA-mediated phosphorylation that governs LAPTM5's lysosomal signaling capacity. Similarly, PMA, by activating PKC, could bolster LAPTM5's involvement in lysosomal protein sorting mechanisms. Ionomycin, by increasing intracellular calcium, may trigger calcium-dependent kinases or phosphatases, potentially augmenting LAPTM5's role in endo-lysosomal trafficking. Furthermore, All-trans Retinoic Acid, by modulating cell differentiation pathways, could promote the enhancement of LAPTM5 function in lysosomal degradation processes, while Insulin, via the PI3K/Akt pathway, and 8-Bromo-cAMP, through PKA activation, might indirectly modulate LAPTM5's localization and stability within lysosomal membranes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which in turn can activate Protein Kinase A (PKA). LAPTM5, associated with lysosomal functions, could be indirectly influenced by PKA-mediated phosphorylation, which may affect its trafficking or stability. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which has been implicated in the regulation of membrane trafficking. Activation of PKC could enhance LAPTM5's role in lysosomal signaling and protein sorting. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular Ca2+ concentrations, potentially affecting calcium-dependent kinases and phosphatases that could modulate LAPTM5's functionality in endo-lysosomal pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans Retinoic Acid influences cell differentiation and growth. For LAPTM5, this compound could enhance its role in lysosomal degradation pathways during differentiation processes. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt pathway, which can influence membrane trafficking. This activation may indirectly enhance LAPTM5's role in lysosomal function and biogenesis. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
Analog of cAMP that can activate PKA. Enhanced PKA activity can indirectly influence LAPTM5 by phosphorylating proteins that interact with or regulate LAPTM5's localization and stability in lysosomes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits the vacuolar type H+-ATPase (V-ATPase), altering endo-lysosomal pH. This could affect LAPTM5's function since lysosomal pH is critical for its protein sorting and degradation activities. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it could indirectly enhance LAPTM5's phosphorylation status, thereby potentially affecting its lysosomal functions. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 is an irreversible cysteine protease inhibitor. By inhibiting lysosomal proteases, E-64 could influence LAPTM5's role in regulating protease activity within the lysosomes. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic Acid, a form of vitamin B3, can influence cellular metabolism and has been shown to affect lysosomal integrity. Its effect on metabolism might enhance LAPTM5's function in lysosomal degradation pathways. | ||||||