L-type calcium channel β1 Inhibitors
Chemical inhibitors of L-type calcium channel β1 subunit operate by obstructing the passage of calcium ions through the voltage-dependent L-type calcium channels, where the β1 subunit plays a crucial role. Nisoldipine, for example, selectively inhibits the influx of calcium by binding to and altering the L-type calcium channels, which includes the β1 subunit. This action results in the reduced formation of active channels and thus prevents calcium ions from entering the cell. Similarly, Nimodipine binds to these channels, impeding the calcium influx necessary for various physiological functions. The action of Nimodipine indirectly affects the L-type calcium channel β1 by diminishing the assembly of the active channel, which in turn reduces the entry of calcium.
Other chemical inhibitors, such as Amlodipine, Verapamil, and Diltiazem, also target the L-type calcium channels, thereby affecting the β1 subunit's ability to facilitate calcium entry into cells. Amlodipine, for instance, specifically inhibits calcium ion influx, which indirectly hampers the functioning of the β1 subunit by blocking the channels' calcium transport capability. Verapamil and Diltiazem both inhibit calcium ion cell entry, which influences the cardiac muscle function and vascular tone. By blocking these channels, Verapamil and Diltiazem indirectly affect the β1 subunit's function by preventing the proper assembly and operation of the channel, thus reducing calcium conductance. Other inhibitors like Isradipine, Felodipine, Lacidipine, and Nicardipine show a similar mode of action by inhibiting the L-type calcium channels, which indirectly affects the β1 subunit, leading to a decrease in calcium ion permeability and the cellular functions associated with it. Clevidipine, Azelnidipine, and Benidipine also follow this pattern, targeting the L-type calcium channels and consequently affecting the β1 subunit's role in the channel complex, thereby reducing the calcium ion influx necessary for various cellular activities. Each of these chemical inhibitors interacts with the L-type calcium channels and thereby modulates the function of the L-type calcium channel β1 subunit.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
Nimodipine binds to and inhibits L-type calcium channels. The inhibition of these channels impedes the calcium influx, which is necessary for various physiological functions. As L-type calcium channel β1 is part of these channels, Nimodipine indirectly inhibits its function by diminishing the formation of the active channel and, consequently, calcium entry. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine selectively inhibits calcium ion influx through L-type calcium channels. The action of Amlodipine can indirectly inhibit L-type calcium channel β1 by blocking these channels' ability to transport calcium, which is essential for vascular smooth muscle function, thereby inhibiting the physiological role of L-type calcium channel β1 as a channel subunit. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil inhibits calcium ion cell entry through L-type calcium channels, which affects cardiac muscle function and vascular tone. By blocking these channels, Verapamil indirectly inhibits the function of L-type calcium channel β1 by preventing the proper assembly and operation of the channel, thereby reducing calcium conductance. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem blocks L-type calcium channels, thereby inhibiting the influx of calcium ions that are critical for cardiac and smooth muscle contraction. This inhibition of calcium entry through the channels indirectly inhibits L-type calcium channel β1 function by preventing the complete and functional assembly of the channel complex in which the β1 subunit is involved. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $88.00 $324.00 | 1 | |
Isradipine is an inhibitor of L-type calcium channels, which affects the calcium ion influx into cells. This action indirectly inhibits L-type calcium channel β1, as it is a component of these channels, and the inhibition of the channel complex results in diminished calcium ion permeability and the associated cellular functions. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Felodipine is known to inhibit L-type calcium channels, thereby reducing the influx of calcium ions. L-type calcium channel β1, as part of these channels, is indirectly inhibited by Felodipine. The drug's action interferes with the operation of the channel complex, thus inhibiting calcium ion passage and the resultant physiological processes. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine inhibits L-type calcium channels, which in turn reduces calcium entry into vascular smooth muscle cells. Since L-type calcium channel β1 is a subunit of these channels, Lacidipine's action indirectly inhibits its activity by preventing channel formation and the subsequent calcium influx necessary for muscle contraction and signaling. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $33.00 $83.00 | 5 | |
Nicardipine inhibits L-type calcium channels, decreasing calcium ion entry into cells, which is vital for cardiac and smooth muscle function. The inhibition of the channels indirectly inhibits L-type calcium channel β1 by disrupting the channel complex's structure and function, in which the β1 subunit plays a crucial role. | ||||||
Azelnidipine | 123524-52-7 | sc-252395 | 10 mg | $86.00 | ||
Azelnidipine selectively inhibits L-type calcium channels, reducing the influx of calcium ions that are essential for vascular smooth muscle function. The inhibition of these channels indirectly inhibits L-type calcium channel β1 by disrupting the channel complex's assembly and function, which depends on the β1 subunit for proper calcium conductance. | ||||||
Benidipine | 105979-17-7 | sc-278724 | 100 mg | $650.00 | ||
Benidipine targets L-type calcium channels, decreasing the calcium ion entry that is critical for the regulation of cardiac and smooth muscle activity. This inhibition of channel function indirectly inhibits L-type calcium channel β1 by hampering the formation of functional channel complexes | ||||||