L-type Ca++ CP α1S Inhibitors
L-type Ca++ CP α1S inhibitors belong to a specific chemical class of compounds that exert their pharmacological effects by selectively targeting and inhibiting the α1S subunit of the L-type calcium channel. These channels play a crucial role in regulating the influx of calcium ions into cells, especially muscle cells, which is essential for various cellular functions. The α1S subunit is an integral part of these channels, and inhibiting its activity can modulate the influx of calcium ions, thereby influencing cellular processes.
By selectively binding to the α1S subunit, these inhibitors effectively block the passage of calcium ions through the L-type calcium channels, thus regulating their function. This mechanism of action can have significant effects on excitation-contraction coupling in cardiac and skeletal muscle cells. Furthermore, it may impact various other cellular activities that rely on calcium signaling pathways, such as neurotransmitter release, hormone secretion, and smooth muscle contraction. Researchers and scientists are interested in studying L-type Ca++ CP α1S inhibitors due to their potential to elucidate the underlying physiological roles of the α1S subunit and L-type calcium channels in different cell types. By understanding the functions and regulatory mechanisms of these channels, researchers hope to gain insights into cellular processes and potential implications for health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine selectively inhibits L-type Ca++ channels (CaV1.2) in cardiac and smooth muscle, leading to decreased intracellular calcium levels, which reduces muscle contraction and dilates arteries. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine acts by specifically blocking L-type Ca++ channels, reducing calcium influx into cardiac and vascular smooth muscle cells, thus lowering blood pressure and myocardial oxygen demand. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Felodipine binds to and inhibits L-type Ca++ channels, decreasing calcium entry into vascular smooth muscle, leading to vasodilation and reduced arterial pressure. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $88.00 $324.00 | 1 | |
Isradipine targets and inhibits L-type Ca++ channels, effectively decreasing calcium ions' entry into vascular smooth muscle and cardiac cells, resulting in vasodilation and decreased blood pressure. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
Nimodipine preferentially inhibits L-type Ca++ channels in cerebral arteries, reducing calcium influx, which helps prevent vasospasm and improves blood flow to the brain. | ||||||
Manidipine | 89226-50-6 | sc-211774 | 10 mg | $278.00 | ||
Manidipine inhibits L-type Ca++ channels, reducing calcium influx into smooth muscle cells, which results in vasodilation and antihypertensive effects. | ||||||
Benidipine | 105979-17-7 | sc-278724 | 100 mg | $650.00 | ||
Benidipine inhibits L-type Ca++ channels, leading to decreased intracellular calcium, vasodilation, and effective blood pressure reduction. | ||||||
Cilnidipine | 132203-70-4 | sc-201485 sc-201485A sc-201485B | 10 mg 50 mg 1 g | $74.00 $284.00 $450.00 | 1 | |
Cilnidipine uniquely inhibits both L-type and N-type Ca++ channels, reducing calcium influx into vascular smooth muscle and sympathetic nerve terminals, resulting in vasodilation and antihypertensive effects. | ||||||