KV2.2 Activators

KV2.2 activators are chemical compounds that can increase the functional activity of KV2.2, a voltage-gated potassium channel. Several different types of potassium channel blockers and openers can enhance KV2.2 activity by affecting other potassium channels and increasing the demand for KV2.2 function. For instance, 4-Aminopyridine and Phrixotoxin-2 are selective blockers of voltage-gated potassium channels. By blocking these channels, they enhance the need for other potassium channels like KV2.2, leading to increased activity of the protein. Similarly, Retigabine is a potassium channel opener that enhances KV2.2 activity by increasing the need for potassium transport, a function that KV2.2 serves.

Furthermore, certain compounds that inhibit or block different types of potassium channels can also enhance the activity of KV2.2. For example, Iberiotoxin, Paxilline, Apamin, and Charybdotoxin are selective blockers of large-conductance calcium-activated potassium channels, and by blocking these channels, they increase the need for other potassium channels such as KV2.2, leading to increased activity of the protein. NS1643, a potent activator of human ether-a-go-go-related gene (hERG) potassium channels, indirectly enhances the need for KV2.2 by activating these channels. Dofetilide and E-4031, selective blockers of rapid component of the delayed rectifier potassium current (IKr), similarly enhance the demand for KV2.2 by blocking these channels. Lastly, compounds like Quinidine and Amiodarone, which block a variety of voltage-gated potassium channels, increase the need for KV2.2 function, thereby enhancing its activity.