KLHL6 Inhibitors
KLHL6 Inhibitors chemical class is primarily built on molecules that modulate the ubiquitin-proteasome system, given KLHL6's association with the E3 ubiquitin ligase family. Compounds such as MLN4924 and Pevonedistat, which target the NEDD8-activating enzyme, indirectly hinder the activation of cullin-RING E3 ligases, which can play a pivotal role in substrate ubiquitination.
Similarly, molecules such as Nutlin-3 and PYR-41 can disrupt the ubiquitination process by respectively interfering with MDM2-p53 interactions or inhibiting the ubiquitin-activating enzyme. Proteasome inhibitors like Bortezomib and ubiquitin conjugation disruptors like NSC697923 exemplify the strategic blockade of the ubiquitin-proteasome pathway, possibly affecting the functional cascade in which KLHL6 is involved. On the other hand, compounds like Thalidomide and Curcumin offer broader modulatory effects, touching upon various aspects of the ubiquitination pathway or protein stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Inhibits NEDD8-activating enzyme, indirectly affecting the activity of cullin-RING E3 ligases. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Disrupts MDM2-p53 interaction, affecting downstream ubiquitination processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can affect proteins subjected to ubiquitination. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Modulates the activity of cereblon, a component of an E3 ubiquitin ligase complex. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Can modulate ubiquitination processes and influence protein stability. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Irreversible ubiquitin-activating enzyme (E1) inhibitor, affecting ubiquitination. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
Inhibits Ubc13-Uev1A interaction, affecting ubiquitin conjugation. | ||||||
PRT4165 | 31083-55-3 | sc-507487 | 10 mg | $134.00 | ||
Inhibits the RING E3 ligase RNF4. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
Inhibits SIRT1, potentially affecting downstream ubiquitination processes. | ||||||