KLHDC1 Inhibitors
KLHDC1 inhibitors represent a class of chemical compounds designed to interfere with the function of the KLHDC1 protein, a member of the Kelch-like protein family. KLHDC1, known for its role in various cellular processes, is associated with the ubiquitin-proteasome system, which is essential for maintaining protein homeostasis by tagging and degrading unnecessary or damaged proteins. The Kelch-like domains within KLHDC1 are involved in protein-protein interactions, often serving as scaffolding structures that facilitate the assembly of multi-protein complexes. KLHDC1, in particular, is known to interact with other proteins involved in cellular signaling pathways, making it a crucial component in regulating protein stability and cellular function. Inhibitors targeting KLHDC1 typically aim to modulate these interactions, potentially altering the protein degradation pathways and thereby affecting downstream cellular processes.
Structurally, KLHDC1 inhibitors may contain specific chemical motifs designed to bind to key regions of the protein, such as its Kelch repeats or other conserved domains critical for its interactions. These inhibitors may employ a range of mechanisms to disrupt KLHDC1 activity, from competitive inhibition at its active sites to inducing conformational changes that hinder its normal function. Understanding the binding affinities, structural dynamics, and kinetic properties of these inhibitors is crucial for elucidating their impact on the protein's function. Research into KLHDC1 inhibitors often focuses on their biochemical properties, such as their specificity, binding modes, and potential off-target effects, all of which are essential for determining how these inhibitors influence broader cellular pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that could prevent the degradation of polyubiquitinated proteins, potentially leading to the accumulation of substrates that could saturate the binding capacity of KLHDC1, thereby functionally inhibiting it. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
An actin polymerization inhibitor that may disrupt cytoskeletal interactions. If KLHDC1 is involved in cytoskeletal organization, this disruption might indirectly inhibit KLHDC1's ability to bind to its protein partners. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
An inhibitor of NEDD8-activating enzyme that prevents the neddylation of cullin proteins. Since cullins are often associated with Kelch domain proteins in the ubiquitination pathway, this could indirectly inhibit KLHDC1. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
A proteasome inhibitor that works similarly to MG132 by preventing the breakdown of polyubiquitinated proteins, potentially leading to non-specific inhibition of KLHDC1 by substrate accumulation. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
A toxin that stabilizes actin filaments; if KLHDC1 is associated with cytoskeletal regulation, stabilizing actin filaments may indirectly inhibit KLHDC1's activity by altering its protein-protein interactions. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that can disrupt cytoskeletal organization by binding to vimentin. If KLHDC1 interacts with intermediate filaments, this could potentially inhibit its function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Known to alter cellular membranes and potentially disrupt membrane-associated proteins. If KLHDC1 is membrane-associated, this could alter its localization and function. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
A microtubule stabilizer that, by altering microtubule dynamics, could affect proteins associated with microtubules. If KLHDC1 is involved in this pathway, it could be indirectly inhibited. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could lead to non-specific inhibition of KLHDC1 by the accumulation of ubiquitinated substrates. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
An inhibitor of actin polymerization that could disrupt any potential actin-related functions of KLHDC1, leading to its functional inhibition by altering its interactions with the actin cytoskeleton. | ||||||