KIR3DL3 Inhibitors
KIR3DL3 inhibitors belong to a specific chemical class designed to modulate the activity of the killer cell immunoglobulin-like receptor 3DL3 (KIR3DL3). KIR3DL3 is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays a crucial role in regulating immune responses. These inhibitors target the function of KIR3DL3, a transmembrane glycoprotein expressed on the surface of natural killer (NK) cells, a type of immune cell involved in the recognition and elimination of infected or abnormal cells.
KIR3DL3 inhibitors are meticulously engineered to interact selectively with the binding site of KIR3DL3, modulating its activity and, consequently, influencing the downstream signaling pathways involved in immune responses. By inhibiting KIR3DL3, these compounds aim to fine-tune the balance of immune activation and tolerance, potentially enhancing the body's ability to mount effective immune responses against aberrant cells. The development of KIR3DL3 inhibitors represents a nuanced approach to manipulating immune function at the molecular level, with the goal of gaining a deeper understanding of immune regulation and potential applications in various contexts where immune modulation is a critical factor. Ongoing research in this field aims to elucidate the precise mechanisms through which KIR3DL3 inhibitors exert their effects, providing valuable insights into the intricate interplay of immune signaling pathways and contributing to the broader understanding of immunology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Immunosuppressive drug that can inhibit calcineurin, affecting downstream NFAT signaling, which is a key regulator of immune response. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Another calcineurin inhibitor, tacrolimus can affect the activation of NK cells and consequently the function of KIR3DL3. | ||||||
Ascomycin | 104987-12-4 | sc-207303B sc-207303 sc-207303A | 1 mg 5 mg 25 mg | $36.00 $173.00 $316.00 | ||
It is an immunosuppressant that has similar actions to tacrolimus but is slightly less potent. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A glucocorticoid that can suppress the immune response, potentially impacting KIR3DL3 activity. | ||||||
Methylprednisolone | 83-43-2 | sc-205749 sc-205749A | 100 mg 500 mg | $115.00 $260.00 | 1 | |
Another glucocorticoid with immunosuppressive effects, it can indirectly affect KIR3DL3 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can affect T-cell proliferation and NK cell activation. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
A derivative of sirolimus, it can also impact mTOR signaling and thus indirectly influence KIR3DL3. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $41.00 $133.00 $663.00 | 2 | |
A synthetic corticosteroid used as an immunosuppressant, it can modulate the immune response and hence the function of KIR3DL3. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Another corticosteroid with similar effects to prednisone. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
An inhibitor of inosine monophosphate dehydrogenase, it can suppress purine synthesis and impact T-cell and B-cell proliferation. | ||||||