KIAA1143 Inhibitors
KIAA1143 Inhibitors encompass a range of chemical compounds that impair the functional activity of KIAA1143 by targeting various mitochondrial processes and energy metabolism pathways. Compounds like Oligomycin A, Antimycin A, Rotenone, 2-Thenoyltrifluoroacetone, and Azide act by inhibiting different components of the mitochondrial electron transport chain, leading to a decrease in ATP production and reduced mitochondrial membrane potential. This could indirectly inhibit KIAA1143 by hampering its functions that are contingent on an intact and polarized mitochondrial membrane and sufficient ATP supply. Similarly, Bongkrekic Acid and Atractyloside, both inhibitors of the adenine nucleotide translocator, disrupt the crucial ADP/ATP exchange across the mitochondrial inner membrane, potentially diminishing KIAA1143 activities tied to energy homeostasis within mitochondria. Palmitoyl-DL-carnitine, by potentially overloading the fatty acid oxidation system, and Calcium Chloride, through the induction of mitochondrial permeability transition pore opening, can also compromise mitochondrial integrity and function, further impairing KIAA1143's associated roles.
Moreover, FCCP, acting as a protonophore, uncouples oxidative phosphorylation, which can negatively impact KIAA1143's function if it is dependent on a proton gradient-driven process. Allopurinol, through its inhibition of xanthine oxidase, could influence purine metabolism and subsequently affect KIAA1143 if its activity is linked to purine-related mitochondrial mechanisms. Lastly, 2-Deoxy-D-glucose inhibits glycolysis, leading to a depletion of ATP levels, which could indirectly inhibit KIAA1143 functions reliant on glycolytic ATP. Collectively, these inhibitors, by targeting specific mitochondrial functions and energy metabolism pathways, contribute to a decrease in KIAA1143's functional activity, highlighting the intricate relationship between mitochondrial health and KIAA1143's role within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A specifically inhibits mitochondrial ATP synthase (Complex V) by binding to the OSCP subunit, leading to a reduction in ATP production. As KIAA1143 is implicated in mitochondrial function, the reduction in ATP levels can diminish KIAA1143's role in ATP-dependent processes. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $418.00 | 10 | |
Bongkrekic Acid inhibits the mitochondrial adenine nucleotide translocator (ANT), preventing ADP/ATP exchange across the mitochondrial inner membrane. This action disrupts mitochondrial energy metabolism, which can diminish the activity of KIAA1143 if it is related to mitochondrial energy homeostasis. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial inner membrane. This uncoupling can decrease ATP synthesis, potentially diminishing KIAA1143's activity if it has a role in processes powered by the mitochondrial proton gradient. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits Complex III in the mitochondrial electron transport chain, preventing electron transfer and reducing ATP synthesis. This inhibition diminishes the mitochondrial membrane potential, which could indirectly inhibit the functional activities of KIAA1143 associated with electron transport and ATP generation. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial Complex I, blocking electron transport and decreasing ATP production. This leads to a reduction in the mitochondrial membrane potential, which could indirectly inhibit KIAA1143's functional activities if they are related to the electron transport chain. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
2-Thenoyltrifluoroacetone is a selective inhibitor of Complex II in the electron transport chain. By inhibiting this complex, 2-Thenoyltrifluoroacetone diminishes the production of reducing equivalents for ATP synthesis, potentially inhibiting any KIAA1143 activity related to mitochondrial energy production. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Azide is a potent inhibitor of Complex IV in the electron transport chain, blocking oxygen reduction and ATP synthesis. This inhibition could indirectly diminish KIAA1143 activity related to mitochondrial oxidative phosphorylation. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol is a xanthine oxidase inhibitor that reduces the production of uric acid. By affecting purine metabolism, allopurinol could indirectly diminish KIAA1143 activity if it is involved in purine-related mitochondrial functions. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride can induce mitochondrial permeability transition pore (mPTP) opening, leading to a decrease in mitochondrial membrane potential. If KIAA1143 is involved in maintaining mitochondrial membrane integrity, increased mPTP opening could diminish its activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose is a glycolysis inhibitor that mimics glucose but cannot be fully metabolized, leading to ATP depletion. This can indirectly diminish KIAA1143 activity if it relies on glycolytically-generated ATP for its function. | ||||||