KIAA0226 Activators
KIAA0226 activators encompass a variety of chemical compounds that can initiate or amplify the signaling pathways involved in the protein's functional activity. Forskolin, by raising intracellular cAMP, indirectly promotes KIAA0226's participation in cellular responses through PKA-mediated phosphorylation events. The non-selective inhibition of phosphodiesterases by IBMX leads to the preservation of cAMP and cGMP, enhancing PKA and PKG activity which may cascade down to KIAA0226, leading to its enhanced functional state. PMA acts as a potent activator of PKC, which may have downstream effects on KIA. KIAA0226 Activators are a collection of chemical compounds that indirectly bolster the functional activity of KIAA0226 through various signaling pathways. Forskolin, by increasing intracellular cAMP levels, indirectly promotes KIAA0226's functional activity by activating PKA, which may phosphorylate target proteins related to KIAA0226, thus enhancing its activity within cellular signaling networks. IBMX, as a non-selective inhibitor of phosphodiesterases, leads to an accumulation of cAMP and cGMP, which can enhance PKA and PKG pathways.
This enhancement has the potential to increase the phosphorylation state and activity of KIAA0226. PMA activates PKC, which in turn could influence signaling pathways involving KIAA0226, potentially enhancing its activity. Ionomycin and A23187, both calcium ionophores, elevate intracellular calcium levels and activate calcium-dependent protein kinases, which may lead to the phosphorylation of KIAA0226 or related proteins, thereby enhancing its activity. Furthermore, the inhibition of protein phosphatases by okadaic acid increases the overall phosphorylation levels in the cell, which could result in augmented activity of KIAA0226 due to its heightened phosphorylated state. Epigallocatechin Gallate (EGCG) and Anisomycin, through their kinase modulation and activation of stress-activated protein kinases, respectively, could shift the phosphorylation balance to favor KIAA0226 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP can activate PKA, which may phosphorylate target proteins, including KIAA0226, thereby enhancing its activity within its associated signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. Increased levels of these cyclic nucleotides can enhance PKA and PKG pathways, potentially leading to the phosphorylation and functional enhancement of KIAA0226. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, or phorbol 12-myristate 13-acetate, is an activator of protein kinase C (PKC). PKC activation can subsequently influence downstream proteins and pathways that may include KIAA0226, thus potentially enhancing its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, which could phosphorylate KIAA0226 or associated proteins, leading to enhanced KIAA0226 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore, similar to ionomycin, that increases intracellular calcium levels. This increase can stimulate calcium signaling pathways to enhance the activity of KIAA0226 by promoting its phosphorylation or interaction with other proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins. This can enhance the phosphorylation state of KIAA0226, indirectly increasing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase-inhibiting properties. By inhibiting certain kinases, EGCG can shift the balance of cellular phosphorylation, potentially enhancing KIAA0226 activity through altered signaling dynamics. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that acts as a protein synthesis inhibitor. It also activates stress-activated protein kinases (SAPKs), which might indirectly increase the activity of KIAA0226 by modulating stress response pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can alter the AKT signaling pathway, which may indirectly enhance KIAA0226 activity by affecting related signaling networks. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibiting p38 MAPK can lead to the alteration of downstream signaling processes, potentially enhancing the functional activity of KIAA0226 through changes in the signaling environment. | ||||||