Keratin 24 Inhibitors

Keratin 24 inhibitors refer to a group of chemicals that can decrease the function or stability of Keratin 24. While direct inhibitors of Keratin 24 are not commonly recognized, there exists a range of compounds that can interfere with the larger keratin family or influence pathways related to keratin stability and function.

Compounds such as Acrylamide and Withaferin A can directly interact with keratins, leading to structural disruption or altered assembly. Agents like DMSO have been noted to disassemble keratin filaments in specific cell types. The status of keratin phosphorylation, which influences filament organization, can be impacted by Staurosporine, Sodium orthovanadate, Genistein, Okadaic acid, and PMA. For instance, Staurosporine's inhibition of protein kinases can alter keratin phosphorylation dynamics. PARP inhibitors, represented by Olaparib, can modulate DNA repair pathways, indirectly affecting keratin expression. Compounds like Jasplakinolide and Cytochalasin D target actin filaments, and changes in actin dynamics can indirectly influence keratin structures. Furthermore, 2,3-Butanedione can form adducts with keratins, offering another avenue of modulation.