KCMF1 Activators
KCMF1 Activators are a class of chemical compounds that enhance the functional activity of KCMF1, a protein known for its role in cellular processes such as the unfolded protein response (UPR). Some KCMF1 activators, such as Tunicamycin, Dantrolene, Thapsigargin, Brefeldin A, and Salubrinal, influence KCMF1's activity by triggering the UPR. Tunicamycin inhibits N-linked glycosylation, Dantrolene reduces intracellular calcium release, Thapsigargin inhibits the SERCA pump, Brefeldin A disrupts the Golgi apparatus structure, and MG132 inhibits the proteasome. These actions lead to the accumulation of unfolded proteins in the endoplasmic reticulum, thus triggering the UPR and leading to the upregulation of KCMF1.
Other KCMF1 activators, such as A23187, Verapamil, 2-Deoxy-D-glucose, Cyclopiazonic acid, and Nigericin, affect KCMF1's activity by disrupting cellular homeostasis. A23187, Verapamil, and Cyclopiazonic acid disrupt calcium homeostasis, while Nigericin disrupts potassium homeostasis. 2-Deoxy-D-glucose inhibits glycolysis, leading to energy stress. These disruptions in homeostasis trigger the UPR, which in turn upregulates KCMF1. Thus, each of these compounds, while structurally diverse, ultimately enhance the functional activity of KCMF1 by influencing specific cellular processes or signaling pathways that KCMF1 is directly involved in.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation which indirectly activates KCMF1. Inhibition of N-linked glycosylation leads to accumulation of unfolded proteins in the endoplasmic reticulum, triggering the unfolded protein response. KCMF1 is known to be upregulated during the unfolded protein response, thus Tunicamycin can indirectly enhance KCMF1 functional activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a ryanodine receptor antagonist that reduces intracellular calcium release from the endoplasmic reticulum. Lowering calcium levels can trigger the unfolded protein response, leading to upregulation of KCMF1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, which leads to depletion of endoplasmic reticulum calcium stores and triggers the unfolded protein response. This can upregulate KCMF1. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus structure, which can lead to the unfolded protein response. KCMF1 is upregulated during this response, and thus Brefeldin A can enhance KCMF1 activity. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is an inhibitor of eIF2alpha dephosphorylation, which can lead to the unfolded protein response. Since KCMF1 is upregulated during this response, Salubrinal can enhance KCMF1 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that disrupts calcium homeostasis. Disruption of calcium homeostasis can trigger the unfolded protein response, leading to upregulation of KCMF1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can disrupt calcium homeostasis. This disruption can trigger the unfolded protein response, leading to upregulation of KCMF1. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis, which can lead to energy stress and trigger the unfolded protein response. As KCMF1 is upregulated during this response, 2-Deoxy-D-glucose can enhance KCMF1 activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid is a specific inhibitor of the SERCA pump which leads to depletion of endoplasmic reticulum calcium stores and triggers the unfolded protein response. This can upregulate KCMF1. | ||||||