KChIP1 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is a calcium channel blocker that inhibits voltage-gated calcium channels. KChIP1 is known to associate with and modulate the A-type potassium channels' function by altering their voltage-dependent properties. By inhibiting calcium channels, bepridil can disrupt the intracellular calcium levels that are necessary for KChIP1 to properly associate with potassium channels, thereby functionally inhibiting KChIP1's modulation of these channels. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is another calcium channel blocker with a similar mechanism to bepridil. It can inhibit the interaction between KChIP1 and A-type potassium channels by altering the calcium dynamics within the cell, leading to a functional inhibition of KChIP1's role in modulating the activity of these channels. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a phenylalkylamine calcium channel blocker, also inhibits calcium influx through L-type calcium channels. This inhibition can decrease the calcium-dependent interaction of KChIP1 with its target potassium channels, thus functionally inhibiting the protein's modulatory effect on channel properties such as gating and conductance. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a dihydropyridine calcium channel blocker that can disrupt the calcium-dependent regulatory function of KChIP1 on A-type potassium channels by reducing calcium currents. This decrease in calcium levels can impair the ability of KChIP1 to modify the channel kinetics and surface expression, leading to its functional inhibition. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine is similar to nifedipine in that it is also a dihydropyridine calcium channel blocker. It can inhibit the functional activity of KChIP1 by diminishing the calcium signal that is crucial for KChIP1's modulation of A-type potassium channels. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
Isradipine, another dihydropyridine calcium channel blocker, functions analogously to amlodipine and nifedipine by inhibiting L-type calcium channels, which would decrease intracellular calcium levels, thereby functionally inhibiting KChIP1 by reducing its regulatory influence on A-type potassium channels. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine is a calcium channel blocker that would inhibit KChIP1 in a similar manner to other dihydropyridines by impairing calcium influx and thus KChIP1's association with and modulation of A-type potassium channels. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine is a dihydropyridine calcium channel blocker that can also decrease the calcium-dependent interactions of KChIP1 with A-type potassium channels, leading to a functional inhibition of the protein's ability to affect these channels' properties. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
Felodipine, another dihydropyridine calcium channel blocker, would inhibit KChIP1 by lowering calcium currents necessary for KChIP1 to exert its modulatory effects on A-type potassium channels, leading to functional inhibition. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine is a long-acting calcium channel blocker that inhibits L-type calcium channels, which would similarly disrupt the calcium-dependent regulation of A-type potassium channels by KChIP1, resulting in the functional inhibition of KChIP1. | ||||||