JMJD1B Activators
The chemical class of JMJD1B activators comprises a diverse range of compounds, primarily influencing chromatin remodeling and gene expression, thereby potentially modulating the activity of JMJD1B. These activators function indirectly by affecting the cellular environment and biochemical pathways that converge on the epigenetic regulation of gene expression, where JMJD1B plays a critical role. Compounds such as 5-Aza-2'-deoxycytidine, Trichostatin A, and Vorinostat are notable for their roles in altering chromatin dynamics. By inhibiting DNA methyltransferases and HDACs, these compounds can lead to a more open chromatin state, potentially enhancing JMJD1B activity by making its substrates more accessible. Additionally, these changes in chromatin structure could indirectly influence JMJD1B's role in transcriptional regulation.
Furthermore, natural compounds like curcumin, resveratrol, and sulforaphane modulate various signaling pathways and cellular processes. By influencing these pathways, these compounds can indirectly affect the transcriptional landscape and chromatin structure, thereby potentially impacting JMJD1B activity. Similarly, dietary components like epigallocatechin gallate (EGCG) and omega-3 fatty acids, through their effects on gene expression and cellular metabolism, can indirectly modulate JMJD1B activity by altering the cellular environment that governs its function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that can lead to changes in chromatin structure and potentially influence JMJD1B activity indirectly by altering the transcriptional landscape. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that affects chromatin remodeling and can indirectly influence JMJD1B by altering histone acetylation levels and subsequent chromatin structure. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another HDAC inhibitor that can change chromatin dynamics and potentially affect JMJD1B activity indirectly through alterations in gene expression and chromatin structure. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Affects various signaling pathways and can potentially influence JMJD1B indirectly by modulating gene expression and chromatin structure. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences various signaling pathways, potentially affecting JMJD1B activity indirectly through its impact on gene expression and chromatin remodeling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Activates Nrf2, a transcription factor that could indirectly influence JMJD1B activity through its role in cellular defense mechanisms and gene expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor that can influence various signaling pathways, possibly affecting JMJD1B activity indirectly by modulating pathways intersecting with gene regulation and chromatin remodeling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Affects multiple cellular pathways and may indirectly influence JMJD1B activity through its broad regulatory effects on gene expression and chromatin structure. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, can modulate various signaling pathways, potentially influencing JMJD1B activity indirectly through its impact on cellular processes and gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, can affect gene expression and chromatin structure, potentially influencing JMJD1B activity indirectly. | ||||||