INTS4 Activators

The INTS4 activators encompass chemicals affecting different cellular and biochemical pathways related to gene expression and RNA processing. Key among them are DNA methyltransferase like 5-Azacytidine and RG108. These chemicals modulate gene transcription, creating variable demands on the Integrator complex, in which INTS4 is a component. Such dynamics indicate the of these to indirectly influence the function and involvement of INTS4 in RNA processing. Similarly, histone modification plays a pivotal role in gene regulation. Chemicals such as C646, a specific p300/CBP histone acetyltransferase, and MS-275, an HDAC, showcase this principle. The Integrator complex's demand can be influenced by these as they alter the gene expression landscape. Methylation, another vital epigenetic mark, is targeted by chemicals like BIX-01294, EPZ004777, UNC0638, and A-366. Each of these affects either G9a or DOT1L methyltransferases, indirectly modulating INTS4 if its function or the Integrator complex activity relates to genes controlled by these methyltransferases.

Furthermore, p53, a crucial transcription factor governing various cellular processes, can also influence the Integrator complex's dynamics. Nutlin-3, by stabilizing p53, showcases how alterations in transcription factor levels can influence the broader RNA processing machinery, including INTS4's role. Lastly, BRD4-p300 interaction is crucial for certain gene expression processes, and YF2's ability to disrupt this interaction represents another avenue through which INTS4's function can be indirectly modulated. Each chemical in this class underscores the complex web of gene regulation and RNA processing and how intricate changes can reverberate across systems to influence specific protein functions, such as that of INTS4.