Importin-8 Activators
Importin-8 Activators encompass a variety of chemical compounds that can indirectly influence the activity of Importin-8 through modulation of cellular processes and signaling pathways. These activators do not interact directly with Importin-8, but their actions within the cell can impact the functions associated with Importin-8, particularly its role in the nuclear import of proteins and RNA molecules. The chemicals listed range from microtubule stabilizers like Paclitaxel and disruptors like Colchicine and Nocodazole, to kinase inhibitors such as Wortmannin and LY294002. Each of these compounds, through their primary mechanisms of action, can alter cellular dynamics and processes in a way that potentially impacts the functioning of Importin-8. For instance, alterations in microtubule dynamics can influence cytoplasmic transport mechanisms, potentially affecting the efficiency and regulation of nuclear import processes in which Importin-8 is involved.
Additionally, compounds like Okadaic Acid and Calyculin A, which inhibit protein phosphatases, can change the phosphorylation state of various proteins, potentially influencing the regulation of Importin-8 activity. Similarly, compounds that induce cellular stress, such as Sodium Arsenite, or those affecting protein folding, like Geldanamycin, can indirectly impact the cellular environment and processes related to Importin-8 function. Overall, Importin-8 Activators represent a diverse group of chemicals that, through their actions on various cellular components and pathways, can indirectly influence the activity of Importin-8. Their effects underscore the complex interplay of cellular mechanisms and the potential for various chemical entities to modulate protein functions indirectly through interconnected cellular networks.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules, preventing their disassembly. By stabilizing these structures, Paclitaxel could indirectly influence cellular transport processes, potentially impacting Importin-8’s role in nuclear import. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin and inhibits microtubule polymerization. This disruption of microtubules could alter cellular transport dynamics, potentially influencing Importin-8-mediated transport to the nucleus. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A marine toxin that selectively inhibits protein phosphatases 1 and 2A, leading to hyperphosphorylation of cellular proteins. This alteration in phosphorylation states could indirectly affect Importin-8's role in nuclear transport. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
A diterpene that activates adenylate cyclase, leading to an increase in intracellular cAMP levels. This elevation can influence various signaling pathways, potentially modulating Importin-8’s activity indirectly. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A fungal metabolite that acts as a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, Wortmannin can affect AKT signaling pathways, potentially impacting Importin-8 function indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A synthetic molecule that also inhibits PI3K. Similar to Wortmannin, LY294002 can alter cell signaling pathways, potentially affecting the activity of Importin-8. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
A toxic inorganic compound that induces oxidative stress and heat shock protein expression in cells. This induced cellular stress could potentially affect nuclear import mechanisms where Importin-8 is involved. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
An antineoplastic agent that disrupts microtubule polymerization. By altering microtubule dynamics, Nocodazole could impact Importin-8-mediated transport processes in the cell. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
A marine toxin that inhibits protein phosphatases 1 and 2A, leading to changes in the phosphorylation state of proteins. These changes could potentially influence Importin-8’s activity. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
A cyclic peptide that disrupts actin filaments, potentially influencing cytoplasmic transport and indirectly affecting processes involving Importin-8. | ||||||