IgA chain C Inhibitors
IgA Chain C inhibitors are a class of chemical compounds designed to specifically target the constant (C) region of immunoglobulin A (IgA) antibodies. The constant region, also known as the Fc region, plays a vital role in mediating interactions between IgA and various immune cells, particularly through binding to Fc receptors, such as the FcαRI receptor (CD89) found on neutrophils, monocytes, and other immune cells. IgA is the primary antibody class involved in mucosal immunity, acting as a first line of defense by neutralizing pathogens and facilitating their clearance from mucosal surfaces. IgA Chain C inhibitors function by blocking the Fc region of IgA, thereby interfering with its ability to bind to these receptors and participate in immune signaling and cellular responses.
The development of IgA Chain C inhibitors focuses on targeting critical binding sites within the Fc region that are responsible for interactions with Fc receptors and other immune components. These inhibitors often work by binding to the conserved regions of the Fc domain, preventing the IgA molecule from engaging with FcαRI or other receptors. This binding is typically mediated by non-covalent forces, including hydrogen bonding, hydrophobic interactions, and van der Waals forces, ensuring selective and stable inhibition of the IgA-Fc receptor interaction. By disrupting the ability of IgA to interact with immune cells, IgA Chain C inhibitors are valuable tools for investigating the specific roles of the IgA Fc region in immune system processes, particularly in the regulation of mucosal immunity and the modulation of immune cell activity. These inhibitors provide researchers with insights into the structural and functional properties of IgA, contributing to a better understanding of its role in immune defense mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone can downregulate the expression of IgA chain C by suppressing the activity of NF-kB, a transcription factor that is essential for the activation of the IgA chain C gene in B cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may decrease IgA chain C synthesis by altering the differentiation pathway of B cells, leading to a reduction in the cells that predominantly produce IgA. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol could reduce IgA chain C levels by hindering the maturation of B cells into IgA-secreting plasma cells through the vitamin D receptor-mediated pathway. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate may decrease the production of IgA chain C by inhibiting the proliferation of B cells and by causing folate deficiency, which is crucial for DNA and RNA synthesis in these cells. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A could suppress the expression of IgA chain C by inhibiting T-cell signals required for B-cell activation and subsequent IgA synthesis. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $37.00 $109.00 | 1 | |
Mycophenolate mofetil could lead to a decrease in IgA chain C expression by selectively inhibiting guanosine nucleotide synthesis in B and T lymphocytes, thus reducing their proliferation and function. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea may downregulate IgA chain C expression by inhibiting ribonucleotide reductase, which is necessary for DNA synthesis in proliferating B cells responsible for IgA production. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine might lead to a reduction in IgA chain C levels by interfering with nucleic acid metabolism, which is critical for the proliferation and differentiation of B cells into IgA-secreting cells. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
6-Mercaptopurine might downregulate IgA chain C expression by disrupting purine nucleotide synthesis, which impairs the division and function of B cells, consequently reducing IgA antibody synthesis. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Lenalidomide could suppress the production of IgA chain C by inhibiting the pro-inflammatory cytokine milieu that is requisite for optimal B cell function, including their differentiation into IgA-secreting plasma cells. | ||||||