IDH3B Inhibitors
IDH3B inhibitors are chemical compounds designed to target the IDH3B (Isocitrate Dehydrogenase 3B) protein, which is a critical enzyme involved in cellular energy metabolism and the citric acid cycle, also known as the Krebs cycle. This enzyme is part of the isocitrate dehydrogenase family and is responsible for catalyzing the conversion of isocitrate to alpha-ketoglutarate (α-KG) in the mitochondria. This reaction is vital for the generation of NADH, a key electron carrier in cellular respiration, and for supplying the cell with α-KG, an essential intermediate in various metabolic pathways, including the tricarboxylic acid cycle and amino acid synthesis.
Inhibitors targeting IDH3B are designed to interact with the protein and modulate its activity, potentially interfering with its ability to catalyze the conversion of isocitrate to α-KG. These inhibitors may operate through various mechanisms, such as binding to specific sites on IDH3B or altering its conformation. By inhibiting IDH3B, these compounds can impact the metabolic flux within the citric acid cycle, affecting the production of NADH and α-KG, which are crucial for cellular bioenergetics and biosynthetic pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A derivative of vitamin A, retinoic acid can modulate gene expression and may downregulate IDH3B in certain cell differentiation pathways. | ||||||
Sodium dichloroacetate | 2156-56-1 | sc-203275 sc-203275A | 10 g 50 g | $54.00 $205.00 | 6 | |
Inhibits pyruvate dehydrogenase kinase, leading to altered metabolism that may indirectly decrease IDH3B expression. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $300.00 $944.00 $7824.00 | 1 | |
As an intermediate of the TCA cycle, high levels could provide feedback inhibition, potentially suppressing IDH3B expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenol that influences various signaling pathways and could modify the expression of genes like IDH3B. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that disrupts ionic gradients, thereby potentially altering metabolism and IDH3B expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can lead to broad changes in cellular metabolism, potentially affecting IDH3B expression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor, which could impact a variety of signaling pathways and possibly downregulate IDH3B expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound from turmeric that affects various signaling molecules and could modulate IDH3B expression. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Commonly known to affect metabolic pathways, metformin might alter IDH3B expression through AMPK activation. | ||||||