Iba1 Inhibitors

Common Iba1 Inhibitors include, but are not limited to Minocycline, Hydrochloride CAS 13614-98-7, Nimesulide CAS 51803-78-2, Resveratrol CAS 501-36-0, Piceatannol CAS 10083-24-6 and Baicalein CAS 491-67-8.

Ionized calcium-binding adapter molecule 1 (Iba1) is a protein primarily recognized for its pivotal role in the immune response processes within the central nervous system (CNS). Found abundantly in microglia, the primary immune cells of the CNS, Iba1 acts as a modulator of membrane ruffling and phagocytosis. These specific functions enable microglia to detect, respond to, and mitigate various forms of neural injuries or anomalies. Due to its integral role, Iba1 is often employed as a marker to identify and study activated microglia in various neuropathological conditions.

Iba1 inhibitors are a class of chemical entities designed to specifically target and modulate the activity of the Iba1 protein. Their primary aim is to regulate or reduce the functions of Iba1, thereby influencing the activities of microglia. These inhibitors can function through multiple mechanisms: some may interact directly with the Iba1 protein, inhibiting its natural activities, while others might target associated pathways or proteins that influence Iba1's expression or function. The intricate mechanisms by which these compounds work underscore the complexity of microglial activation and its broader implications in the CNS.