HUNK Inhibitors
HUNK inhibitors are chemicals that targets a cellular enzyme known as HUNK (Hormonally Upregulated Neu-associated Kinase). These inhibitors interact with the active site of the HUNK enzyme, thereby modulating its activity. HUNK is a serine/threonine kinase that plays a role in intracellular signaling pathways. The inhibitors typically feature a molecular structure that allows them to bind to the enzyme's active site through various interactions, including hydrogen bonding, van der Waals forces, and hydrophobic interactions. This binding interaction leads to the alteration of HUNK's catalytic activity, influencing its role in cellular signaling cascades.
The development of HUNK inhibitors involves careful design and optimization of their chemical structures to ensure selective and potent inhibition. These inhibitors have garnered interest in research due to their potential implications in understanding the regulatory mechanisms of cellular processes where HUNK is involved.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XL413 | 1169562-71-3 | sc-474909 | 5 mg | $275.00 | ||
XL413 functions as an ATP-competitive inhibitor of HUNK, blocking its catalytic activity and interfering with the phosphorylation of its substrates. | ||||||
AZD1208 | 1204144-28-4 | sc-503188 | 10 mg | $322.00 | 1 | |
AZD1208 suppresses HUNK activity by targeting its ATP-binding domain, obstructing its ability to phosphorylate downstream targets involved in cell growth. | ||||||
LY2784544 | 1229236-86-5 | sc-364734 sc-364734A | 5 mg 25 mg | $235.00 $863.00 | ||
LY2784544 is an HUNK inhibitor that impedes its kinase activity, curtailing the phosphorylation of key substrates engaged in cancer cell growth and survival. | ||||||
Foretinib | 849217-64-7 | sc-364492 | 5 mg | $129.00 | 6 | |
EXEL-2880 (Foretinib) hinders HUNK activation by binding to its ATP-binding pocket, interfering with its catalytic function and attenuating downstream signaling. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC-0638 modulates HUNK activity by binding to its active site, disrupting its ability to phosphorylate downstream targets and affecting cancer cell survival. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
BIRB-796 functions as an HUNK inhibitor by occupying its ATP-binding pocket, blocking its catalytic function and subsequent phosphorylation of cellular proteins. | ||||||