HSPC144 Activators
HSPC144 can be classified based on their mode of action, primarily targeting the cyclic AMP (cAMP) signaling pathway. Several of these chemicals function by directly or indirectly increasing the intracellular concentration of cAMP, which is a pivotal second messenger in cellular signaling. Forskolin, a well-known diterpene, directly stimulates adenylate cyclase, leading to a rapid increase in cAMP levels. As cAMP accumulates, it activates protein kinase A (PKA), which in turn can phosphorylate various proteins, including HSPC144, thus facilitating its activation. Similarly, Isoproterenol, a synthetic catecholamine, activates beta-adrenergic receptors that also stimulate adenylate cyclase, further amplifying cAMP production. The subsequent activation of PKA can lead to the phosphorylation and consequent activation of HSPC144.
Other chemicals operate by inhibiting the degradation of cAMP, thereby sustaining its cellular levels and prolonging its signaling effect. Compounds such as Vardenafil, Cilostazol, Anagrelide, Rolipram, IBMX, Zaprinast, and Dipyridamole all share a common mechanism of inhibiting different isoforms of phosphodiesterases (PDEs), enzymes responsible for cAMP breakdown. The inhibition of PDEs results in an accumulation of cAMP within the cell. This elevation in cAMP triggers PKA activation, which is then capable of phosphorylating HSPC144. Luteolin, another chemical activator, similarly leads to increased cAMP levels by inhibiting PDE, although its precise mechanism of action may vary. The consistent theme across these chemical activators is the elevation of intracellular cAMP and subsequent activation of PKA, which then has the potential to activate HSPC144 through phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate various target proteins, potentially including HSPC144, thereby leading to its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, resulting in increased cAMP production via adenylate cyclase activation. This rise in cAMP levels can activate PKA, which may then phosphorylate and activate HSPC144. | ||||||
Parathyroid hormone fragment (1-34) | 52232-67-4 | sc-487943 | 100 µg | $185.00 | ||
Parathyroid hormone fragment PTH(1-34) binds to the PTH receptor, leading to cAMP production and PKA activation. PKA can phosphorylate target proteins, including potentially HSPC144, leading to its activation. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil inhibits phosphodiesterase-5, preventing cAMP degradation, which results in increased levels of cAMP. The increase in cAMP enhances PKA activity which may subsequently phosphorylate and activate HSPC144. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a phosphodiesterase-3 inhibitor, which leads to an increase in cAMP levels. The elevated levels of cAMP can activate PKA, which could target and phosphorylate HSPC144, resulting in activation. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits phosphodiesterase-3, increasing cAMP levels which activate PKA. PKA then could phosphorylate HSPC144, thus potentially leading to its activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase-4, which leads to increased cAMP levels in the cell. The cAMP activates PKA, which might phosphorylate HSPC144, resulting in its activation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin has been shown to increase cAMP levels by inhibiting phosphodiesterase. The subsequent activation of PKA could lead to phosphorylation and activation of HSPC144. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which causes an increase in cAMP levels, thereby activating PKA. PKA could then phosphorylate HSPC144, leading to its activation. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast selectively inhibits phosphodiesterase-5, causing an increase in cAMP levels which activates PKA. PKA could then phosphorylate HSPC144, which would lead to its activation. | ||||||