HoxC13 Activators
HoxC13 activators are a class of chemical compounds that interact with the HoxC13 gene, a member of the Homeobox gene family. These activators are involved in the regulation of transcription factors that are critical for the development of various tissues in living organisms. The Homeobox genes contain a well-conserved DNA sequence that encodes the homeodomain, a protein domain that can bind to DNA and modulate the expression of target genes. Specifically, HoxC13 has been found to play a significant role in the development of hair, nails, and skin. Activators of this gene typically function at the molecular level by increasing the expression of HoxC13, which in turn can influence the cellular mechanisms underlying the development and maintenance of these integumentary structures.
The interaction between HoxC13 activators and the HoxC13 gene involves complex biochemical pathways. These activators may bind directly to the gene's promoter region, enhancing its interaction with transcriptional machinery, or they may modulate the activity of other signaling molecules and cofactors that regulate HoxC13 expression. The precise mechanisms of action for these activators can vary widely, depending on their chemical structure and the biological context of their activity. Moreover, the regulation of HoxC13 is a highly orchestrated process that is temporally and spatially specific, and the activators are part of a larger network of genetic and epigenetic factors that ensure the correct patterns of gene expression. Understanding the behavior of HoxC13 activators and their role in gene expression is an area of ongoing research, contributing to a broader knowledge of genetic regulation and cellular differentiation processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence the differentiation of various cells and tissues, including those where HoxC13 plays a role. It modulates retinoic acid receptors, which are known to regulate the expression of homeobox genes, thereby potentially enhancing the functional activity of HoxC13 in processes like hair follicle development. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, thereby increasing cyclic AMP levels within cells. Elevated cAMP can activate protein kinase A, which can lead to changes in the phosphorylation state of transcription factors and coactivators involved in gene regulation. As such, this might enhance HoxC13's functional activity indirectly by modifying the cellular environment where HoxC13 exerts its regulatory functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which is involved in numerous signaling cascades. This activation can lead to alterations in cell proliferation and differentiation pathways, potentially affecting the developmental processes governed by HoxC13. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium concentrations. The increase in calcium can activate signaling pathways that intersect with developmental pathways influenced by HoxC13, potentially enhancing its regulatory activity in those pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
This cAMP analog permeates cell membranes and mimics the action of endogenous cAMP, activating protein kinase A, which in turn can modulate the activity of transcription factors and enhance gene expression patterns in which HoxC13 may be involved. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor, which can lead to a more relaxed chromatin state and potentially increase the accessibility of transcription factors to DNA. This can enhance the expression and functional activity of various genes, including homeobox genes like HoxC13 in the context of epigenetic regulation of development. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-azacytidine can alter epigenetic marks on DNA, potentially leading to altered gene expression patterns. This could enhance the functional activity of HoxC13 by affecting the epigenetic state of cells in developmental pathways. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-estradiol binds to estrogen receptors, which can regulate gene transcription. The alteration of gene expression patterns through estrogen receptor signaling can indirectly influence HoxC13's activity in tissues where estrogen signaling plays a role in development and differentiation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3β, leading to the stabilization and accumulation of β-catenin, a component of the WntGiven the constraints of the task and the nature of the protein HoxC13, the following table lists chemicals that, based on their known biological activities, could logically be expected to indirectly enhance the functional activity of HoxC13: | ||||||