Date published: 2025-9-5

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Homobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of homobifunctional crosslinkers for use in various applications. Homobifunctional crosslinkers are chemical reagents that possess two identical reactive groups, enabling them to covalently link two similar functional groups within or between molecules. These crosslinkers are crucial in scientific research for studying protein-protein interactions, stabilizing protein structures, and creating multi-subunit complexes. Researchers utilize homobifunctional crosslinkers to investigate the spatial organization and dynamics of macromolecular assemblies, providing insights into the structural and functional relationships within biological systems. These crosslinkers are also employed in the development of biomaterials, where they enhance the mechanical properties and stability of synthetic polymers and hydrogels. In addition, homobifunctional crosslinkers play a significant role in immobilizing enzymes and other bioactive molecules onto solid supports, facilitating their use in biosensors, bioassays, and biocatalysis. By offering a comprehensive selection of high-quality homobifunctional crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving innovations in the understanding of molecular interactions and the development of new biotechnological applications. View detailed information on our available homobifunctional crosslinkers by clicking on the product name.

Items 1 to 10 of 60 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Disuccinimidyl glutarate

79642-50-5sc-285455
sc-285455B
sc-285455C
sc-285455D
sc-285455A
100 mg
1 g
5 g
10 g
500 mg
$160.00
$800.00
$2560.00
$5100.00
$415.00
24
(1)

Disuccinimidyl glutarate is a homobifunctional crosslinker that features two reactive N-hydroxysuccinimide (NHS) ester groups, enabling it to form stable amide bonds with primary amines on proteins or other biomolecules. This dual reactivity facilitates the creation of covalent linkages, enhancing molecular stability and specificity in conjugation reactions. Its unique structure allows for precise control over the spatial arrangement of linked entities, influencing molecular interactions and functional outcomes in complex biological systems.

Glutaraldehyde solution, 70% w/w

111-30-8sc-257558
10 ml
$46.00
1
(1)

Glutaraldehyde solution, 70% w/w, acts as a homobifunctional crosslinker, characterized by its two aldehyde groups that readily react with nucleophiles, such as amines and thiols. This dual reactivity promotes the formation of stable covalent bonds, facilitating the creation of intricate networks in various materials. Its ability to induce crosslinking enhances structural integrity and alters physical properties, such as solubility and mechanical strength, making it a versatile agent in diverse chemical applications.

DIDS, Disodium Salt

67483-13-0sc-203919A
sc-203919B
sc-203919
sc-203919C
25 mg
100 mg
250 mg
1 g
$50.00
$160.00
$280.00
$670.00
6
(1)

DIDS, Disodium Salt, serves as a homobifunctional crosslinker, featuring two reactive sulfonate groups that engage in selective interactions with biomolecules. Its unique ability to form stable covalent bonds through nucleophilic attack allows for the precise modification of proteins and polysaccharides. This specificity enhances the formation of complex molecular architectures, influencing reaction kinetics and enabling tailored physical properties, such as increased rigidity and altered solubility in various environments.

Glutaraldehyde solution, 25% w/w

111-30-8sc-300764A
sc-300764
sc-300764B
10 ml
100 ml
1 L
$20.00
$51.00
$180.00
1
(1)

Glutaraldehyde solution, 25% w/w, acts as a homobifunctional agent with two aldehyde groups that readily participate in condensation reactions. This dual reactivity facilitates the formation of crosslinks between amine-containing compounds, promoting the creation of intricate networks. Its rapid reaction kinetics enable efficient bonding, while the resulting structures exhibit enhanced mechanical strength and stability. Additionally, the solution's reactivity can be finely tuned by adjusting pH, influencing the overall interaction dynamics in various systems.

Dimethyl pimelimidate dihydrochloride

58537-94-3sc-268943
sc-268943A
250 mg
1 g
$60.00
$74.00
1
(3)

Dimethyl pimelimidate dihydrochloride serves as a homobifunctional crosslinker, featuring two reactive imidate groups that engage in nucleophilic attack, particularly with amines. This compound exhibits a unique ability to form stable covalent bonds, leading to the creation of robust polymeric networks. Its reaction kinetics are influenced by solvent polarity and temperature, allowing for controlled crosslinking rates. The resulting structures often display improved thermal and chemical resistance, making them suitable for diverse applications.

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)

57757-57-0sc-266859
500 mg
$228.00
(1)

3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester) acts as a homobifunctional crosslinker, characterized by its two N-hydroxysuccinimide ester groups that readily undergo nucleophilic substitution. This compound facilitates the formation of disulfide bonds, enhancing the stability of crosslinked structures. Its reactivity is influenced by pH and the presence of nucleophiles, allowing for precise control over the crosslinking process and the resulting material properties.

Suberic acid bis(N-hydroxysuccinimide ester)

68528-80-3sc-253611
sc-253611A
500 mg
1 g
$107.00
$224.00
(0)

Suberic acid bis(N-hydroxysuccinimide ester) serves as a homobifunctional linker, featuring dual N-hydroxysuccinimide ester moieties that engage in selective nucleophilic reactions. This compound exhibits a unique ability to form stable amide bonds, promoting efficient conjugation between biomolecules. Its reactivity is modulated by environmental factors, enabling tailored crosslinking strategies that influence the mechanical and chemical properties of the resulting networks.

3,3′-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester

81069-02-5sc-206694
100 mg
$296.00
(0)

3,3'-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester acts as a homobifunctional crosslinker, characterized by its two sulfosuccinimidyl ester groups that facilitate targeted conjugation. This compound exhibits a propensity for forming disulfide bonds, enhancing stability in various environments. Its unique reactivity allows for selective interactions with amine-containing molecules, enabling the formation of robust networks that can be fine-tuned for specific applications.

1,2-Ethanediyl Bismethanethiosulfonate

55-95-8sc-208746
25 mg
$395.00
3
(1)

1,2-Ethanediyl Bismethanethiosulfonate serves as a homobifunctional crosslinker, distinguished by its dual methanethiosulfonate groups that promote efficient thiol-mediated reactions. This compound exhibits a remarkable ability to form stable thioether linkages, facilitating the creation of complex molecular architectures. Its reactivity profile allows for rapid conjugation with thiol-containing substrates, enabling precise control over polymerization and network formation in diverse chemical environments.

DTME

71865-37-7sc-214925A
sc-214925
sc-214925B
sc-214925C
sc-214925D
5 mg
10 mg
25 mg
50 mg
100 mg
$199.00
$331.00
$556.00
$1122.00
$2045.00
(0)

DTME is a homobifunctional compound characterized by its unique ability to engage in selective nucleophilic reactions due to its acid halide functionality. This compound exhibits a high reactivity towards amines and alcohols, leading to the formation of stable amide and ester bonds. Its distinct reaction kinetics allow for rapid and efficient coupling, making it ideal for constructing intricate molecular frameworks. Additionally, DTME's physical properties enhance its compatibility with various solvents, broadening its application potential in synthetic chemistry.