HLA-B Activators
HLA-B is a major histocompatibility complex (MHC) class I molecule that plays a critical role in the immune system by presenting peptide antigens to cytotoxic T lymphocytes. This process is vital for the immune surveillance against infected or malignant cells. The functionality of HLA-B is central to the adaptive immune response, enabling the recognition and elimination of cells displaying foreign peptides from pathogens or abnormal cellular processes. The expression and correct folding of HLA-B on the cell surface are necessary for its interaction with T cell receptors, initiating a cascade of immune responses that lead to the activation of cytotoxic T cells and, consequently, the targeting of cells presenting non-self antigens.
The activation and functionality of the HLA-B protein are influenced by various biochemical and cellular pathways that ensure its stability, proper folding, and presentation of antigenic peptides. Essential ions and molecules, such as zinc, magnesium, and calcium, play pivotal roles in stabilizing the structure of HLA-B and facilitating its interaction with antigen peptides and T cell receptors. Furthermore, the energy provided by glucose metabolism, the antioxidant protection offered by compounds like Vitamin C, and the osmotic balance maintained by electrolytes are crucial for the optimal functioning of HLA-B. These factors collectively support the immune system's capacity to identify and respond to antigens presented by HLA-B, highlighting the complex interplay of cellular components and processes that underpin the immune recognition and response mechanisms mediated by HLA-B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
Sodium chloride, through osmotic balance, maintains cellular homeostasis, ensuring the optimal environment for HLA-B protein activity. This ionic balance is crucial for maintaining the conformation and function of the HLA-B protein on the cell surface, facilitating its role in immune recognition. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium sulfate plays a pivotal role in stabilizing cellular membranes and ion channels, directly supporting the functional integrity of the HLA-B protein. By maintaining cellular magnesium levels, it indirectly promotes the activity of enzymes essential for HLA-B's role in antigen presentation. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose is essential for energy production within cells, indirectly supporting the energy-dependent processes involved in the expression and function of HLA-B protein. Adequate glucose levels ensure the ATP availability required for the proper folding and surface expression of HLA-B. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
Potassium chloride is vital for maintaining cellular membrane potential, which is crucial for the proper functioning of the HLA-B protein in immune surveillance. The maintenance of intracellular potassium levels influences cellular signaling pathways that support HLA-B activity. | ||||||
Zinc sulfate solution | 7733-02-0 | sc-251451 | 250 ml | $112.00 | ||
Zinc sulfate enhances immune function by supporting the structural integrity of proteins, including HLA-B. Zinc ions are critical for the enzymatic activities that facilitate HLA-B's role in antigen processing and presentation, thereby activating its immune surveillance function. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate is involved in redox reactions and enzyme co-factor functions that are essential for the biosynthesis and activity of proteins, including HLA-B. Copper levels influence the functional capacity of HLA-B to mediate immune responses. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium chloride plays a crucial role in signaling pathways that regulate the activity of immune cells expressing HLA-B. Calcium ions are essential for the activation of signaling cascades that enhance the function of HLA-B in antigen presentation and immune recognition. | ||||||
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $21.00 $29.00 $43.00 $84.00 $697.00 | 1 | |
Sodium bicarbonate helps maintain physiological pH levels, ensuring the optimal conformation and activity of the HLA-B protein. Proper pH levels are critical for the structural stability of HLA-B, enabling effective antigen presentation. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $73.00 $109.00 | ||
Iron(II) sulfate is essential for cellular metabolism and the synthesis of proteins, including HLA-B. Iron ions support the proliferation of immune cells and the expression of HLA-B, thereby facilitating its role in immune surveillance. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a precursor for the synthesis of nitric oxide, a signaling molecule that influences various immune processes. Increased nitric oxide production can enhance the function of immune cells expressing HLA-B, promoting its activity in antigen presentation. | ||||||