Histone Modification
Items 51 to 60 of 101 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $99.00 $536.00 | 1 | |
CI 994 is a selective inhibitor of histone methyltransferases, particularly targeting the enzyme EZH2. By interfering with the methylation of histone H3 at lysine 27, it disrupts the formation of repressive chromatin structures. This alteration enhances the accessibility of transcriptional machinery to DNA, facilitating gene activation. The compound's specificity for certain methyltransferases underscores its potential to fine-tune epigenetic landscapes, impacting cellular differentiation and proliferation. | ||||||
PTACH | 848354-66-5 | sc-253326 | 2 mg | $216.00 | ||
PTACH is a potent histone modification agent that acts as an acylating agent, influencing the acetylation status of histones. By promoting the transfer of acetyl groups to lysine residues, it alters chromatin structure, leading to a more open configuration. This modification enhances transcriptional activity by facilitating the recruitment of transcription factors and co-activators. Its unique reactivity with specific amino acid side chains allows for targeted epigenetic modulation, impacting gene expression dynamics. | ||||||
BML-266 | 96969-83-4 | sc-221371 sc-221371A | 10 mg 50 mg | $173.00 $666.00 | 1 | |
BML-266 is a selective histone modification compound that functions as a potent inhibitor of histone deacetylases (HDACs). By disrupting the deacetylation process, it stabilizes acetylated histones, thereby promoting a relaxed chromatin state. This alteration in histone acetylation enhances the accessibility of DNA to transcription machinery, influencing gene expression patterns. Its specificity for certain HDAC isoforms allows for nuanced regulation of epigenetic landscapes, impacting cellular processes. | ||||||
Oxamflatin | 151720-43-3 | sc-205960 sc-205960A | 1 mg 5 mg | $151.00 $470.00 | 4 | |
Oxamflatin is a histone modification agent that acts as a selective inhibitor of histone methyltransferases. By interfering with the methylation of histones, it alters the chromatin structure, leading to a more compact or open configuration depending on the context. This modulation of histone methylation can significantly affect transcriptional regulation and chromatin dynamics, influencing cellular signaling pathways and gene expression profiles. Its unique interaction with specific methyltransferase enzymes allows for targeted epigenetic modulation. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is a potent inhibitor of histone deacetylases, influencing the acetylation status of histones and thereby modulating chromatin accessibility. This compound selectively disrupts the deacetylation process, leading to an accumulation of acetylated histones, which promotes a more relaxed chromatin structure. The resulting changes in histone acetylation can significantly impact gene expression and cellular processes by altering the recruitment of transcription factors and chromatin remodelers. | ||||||
BML-210 | 537034-17-6 | sc-221369 sc-221369A | 1 mg 5 mg | $92.00 $277.00 | ||
BML-210 is a selective modulator of histone methylation, specifically targeting histone methyltransferases. By binding to the active site of these enzymes, it alters their catalytic efficiency, leading to a distinct pattern of histone methylation marks. This compound influences chromatin dynamics by stabilizing specific methylation states, which can affect the recruitment of chromatin-associated proteins and the overall epigenetic landscape, thereby impacting transcriptional regulation. | ||||||
Histone Deacetylase | sc-221728 | 2 ml | $254.00 | |||
Histone Deacetylase (HDAC) plays a crucial role in the regulation of gene expression through the removal of acetyl groups from histone proteins. This deacetylation process enhances the interaction between histones and DNA, leading to a more compact chromatin structure. By modulating the accessibility of transcription factors, HDAC influences various cellular pathways, including cell cycle progression and differentiation, thereby shaping the epigenetic landscape and cellular identity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid acts as a potent inhibitor of histone deacetylases, disrupting the normal deacetylation process and promoting histone acetylation. This alteration in histone modification leads to a more relaxed chromatin structure, enhancing gene accessibility. The compound's unique ability to stabilize acetylated histones influences transcriptional activity and can affect various signaling pathways, ultimately impacting cellular functions and epigenetic regulation. | ||||||
HC Toxin | 83209-65-8 | sc-200884 | 1 mg | $158.00 | 1 | |
HC Toxin functions as a selective modulator of histone methylation, specifically targeting histone methyltransferases. By binding to these enzymes, it alters their activity, leading to an accumulation of specific methylation marks on histones. This modification can result in a compact chromatin structure, thereby repressing gene expression. The compound's unique interaction with the methylation machinery can influence cellular differentiation and developmental pathways, highlighting its role in epigenetic regulation. | ||||||
Binucleine 2 | 220088-42-6 | sc-202500 | 5 mg | $162.00 | ||
Binucleine 2 acts as a potent inhibitor of histone acetylation, specifically interacting with histone acetyltransferases. Its dual binding sites facilitate a conformational change in these enzymes, disrupting their catalytic activity. This interference leads to a decrease in acetylation levels on histones, promoting a more open chromatin state. The compound's unique mechanism of action can significantly impact transcriptional regulation and chromatin dynamics, underscoring its role in epigenetic modulation. | ||||||