HC Toxin CAS: 83209-65-8
MF: C21H32N4O6
MW: 436.5
An HDAC inhibitor.

HC Toxin (CAS 83209-65-8)

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同义词: Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
应用; An HDAC inhibitor
CAS号码: 83209-65-8
分子量: 436.5
分子式: C21H32N4O6
* 参考分析证明 大量特定数据 (包括水 含量).
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HC Toxin is a potent, cell-permeable HDAC (histone deacetylase) inhibitor. HC Toxin inhibits HDACs in maize, Physarum and chicken. HC Toxin has displayed antiprotozoal and antineoplastic activity. HC toxin has induced the expression of the gamma-globin gene in erythroid cells. Antiproliferative activity against T47D human breast cancer cells and cultured mastocytoma cells has been observed with HC toxin treatment.


参考文献

1. Walton, J D., et al., 1985. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Experientia. 41(3): 348-50. PMID: 3918884
2. Brosch, G., et al., 1995. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. The Plant cell. 7(11): 1941-50. PMID: 8535144
3. Ross, J., et al., 1996. Comments on the article "Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics" [(1996) Proc. Natl. Acad. Sci. USA 93, 7452-7453]. Proceedings of the National Academy of Sciences of the United States of America. 93(25): 14314; discussion 14315. PMID: 8962046
4. McCaffrey, P G., et al., 1997. Induction of gamma-globin by histone deacetylase inhibitors. Blood. 90(5): 2075-83. PMID: 9292546
5. Joung, Ki Eun., et al., 2004. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Archives of pharmacal research. 27(6): 640-5. PMID: 15283467
6. Walton, Jonathan D., et al., 2006. HC-toxin. Phytochemistry. 67(14): 1406-13. PMID: 16839576

物理状态 :
Solid
来源于 :
Helminthosporium carbonium
溶解度 :
Soluble in DMSO.
保存 :
Store at -20° C
沸点 :
819.18° C at 760 mmHg (Predicted)
密度 :
1.29 g/cm3 (Predicted)
折射率 :
n20D 1.56 (Predicted)
IC50 :
E. tenella HDAC: IC50 = 30 nM; Histone deacetylase 11: IC50 = 430 nM (human)
pK值 :
pKa: 13.33
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
23724535
MDL 号码 :
MFCD00133388
SMILES :
CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3

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PMID: # 24227836  Shin, HJ. et al. 2014. J. Virol. 88: 1281-92.

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