Histone cluster 2 H4A Inhibitors
Histone cluster 2 H4A inhibitors constitute a specific chemical class designed to selectively target and modulate the activity of the histone cluster 2 H4A protein. Histones are crucial proteins involved in chromatin structure and regulation, with histone cluster 2 H4A being a member of the histone H4 family. These inhibitors are intricately designed to interact with the histone cluster 2 H4A protein, influencing its molecular function within the context of chromatin dynamics and epigenetic regulation.
The molecular architecture of histone cluster 2 H4A inhibitors is meticulously crafted to engage specific binding sites on the histone protein, inducing changes in its conformation and dynamics. Histone modifications, including acetylation, methylation, and phosphorylation, play pivotal roles in regulating gene expression and chromatin accessibility. By selectively inhibiting histone cluster 2 H4A, these inhibitors serve as essential tools in laboratory research, enabling scientists to investigate the intricate interplay between histone modifications and epigenetic regulation. Understanding the nuanced functions of histone cluster 2 H4A and its modulation contributes to advancing our comprehension of the complex regulatory mechanisms governing chromatin structure and gene expression, shedding light on fundamental aspects of cellular biology and molecular processes.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
An inhibitor of DNA methyltransferases, potentially leading to hypomethylation and altered gene expression, including that of histones. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A histone deacetylase inhibitor, which could increase histone acetylation levels, potentially disrupting normal histone gene regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Another histone deacetylase inhibitor that may lead to hyperacetylation of histones and affect their gene expression patterns. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A short-chain fatty acid that acts as a histone deacetylase inhibitor, potentially altering histone modification and expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds to GC-rich sequences in DNA, potentially disrupting transcription factor binding to histone gene promoters. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interferes with DNA-dependent RNA synthesis by inhibiting RNA polymerase, which could reduce histone mRNA levels. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
An antifolate that inhibits dihydrofolate reductase, leading to reduced DNA synthesis and potentially affecting histone gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to intercalate into DNA, which could affect DNA replication and transcription, including that of histones. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that could disrupt the normal pattern of histone gene expression by altering chromatin structure. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that has been shown to inhibit the transcription of various genes and may affect histone gene expression. | ||||||