Histone cluster 1 H3H Inhibitors
Histone cluster 1 H3H Inhibitors constitute a specialized class of chemical compounds designed to selectively impede the activity of histone cluster 1, with a specific emphasis on the H3H subtype. Histones play a pivotal role in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H3H designation refers to a variant of histone H3, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H3H becomes a focal point for research aimed at unraveling the intricacies of chromatin dynamics and gene regulation.
The development of Histone cluster 1 H3H Inhibitors necessitates a comprehensive understanding of the structural characteristics of histone H3H and its specific role within chromatin organization. These inhibitors are intricately engineered for specificity, aiming to selectively bind to key regions of Histone cluster 1 H3H and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H3H, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor. By reducing DNA methylation, it could potentially lead to the reactivation of silenced genes and alter gene expression patterns, including those of histone genes. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine acts as a DNA methyltransferase inhibitor and could cause DNA demethylation, which in turn might influence gene expression profiles, potentially decreasing the transcription of histone genes such as H3H. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
This phenolic compound can affect NF-κB pathway and has been reported to possess histone deacetylase inhibitory activity, potentially leading to alterations in gene expression, including that of histone genes. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX-01294 is a histone methyltransferase inhibitor, specifically targeting G9a, which could lead to changes in histone methylation status and consequently affect the expression of certain genes, including histone encoding genes. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is a known inhibitor of histone methyltransferase, particularly the SUV39H1, and could affect histone methylation patterns, potentially resulting in altered expression of histone genes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can modulate various signaling pathways and has been shown to affect histone acetylation and methylation, which may influence gene expression, possibly impacting histone gene transcription. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $50.00 $135.00 | ||
(-)-Epicatechin is known to interact with multiple cellular targets and could potentially influence epigenetic marks, like DNA methylation and histone modification, thereby affecting gene expression. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine has been shown to affect the levels of reactive oxygen species and may influence various cellular pathways, including those involved in epigenetic regulation of gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a selective histone deacetylase inhibitor that can modulate gene expression, which may include the downregulation of histone proteins. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966 is a selective histone deacetylase 3 (HDAC3) inhibitor, which might modify chromatin structure and affect the transcription of various genes, including those encoding histones. | ||||||