Date published: 2026-4-25

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HEXB Inhibitors

Chemical inhibitors of HEXB encompass a diverse group of compounds that potentially influence HEXB activity indirectly through modulation of metabolic pathways, lysosomal function, and glycosidase activities. The first group of these inhibitors includes compounds that target glycosphingolipid metabolism. Miglustat and Eliglustat, by inhibiting glucosylceramide synthase, can alter the availability of substrates for HEXB, thereby potentially influencing its activity. Ambroxol and Pyrimethamine, through their effects on lysosomal function and cellular metabolism, may also impact HEXB indirectly. Inhibitors like Conduritol B epoxide, Nojirimycin, Deoxynojirimycin, Castanospermine, Swainsonine, and 1-Deoxymannojirimycin target various glycosidases and glycoprotein processing enzymes. By affecting these related enzymes, they might influence HEXB's role in glycoside degradation and processing. The second group comprises compounds that affect HEXB through broader cellular mechanisms. Genistein, a tyrosine kinase inhibitor, can indirectly affect HEXB by altering cell signaling pathways that may be involved in lysosomal function and enzyme regulation. Cyclophosphamide, as an alkylating agent, can potentially influence HEXB through its broader impacts on cellular metabolism, stress responses, and lysosomal activity.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(Z)-Pugnac

132489-69-1sc-204415A
sc-204415
5 mg
10 mg
$224.00
$380.00
3
(1)

(Z)-Pugnac, as a hexose-based acid halide, showcases unique reactivity through its electrophilic carbonyl group, which readily participates in nucleophilic acyl substitution reactions. This compound exhibits a distinct preference for interacting with primary amines, leading to the formation of stable amides. Its structural configuration allows for enhanced steric accessibility, influencing reaction kinetics and selectivity. Additionally, the presence of halogen atoms contributes to its reactivity profile, facilitating diverse synthetic pathways.

Galacto-PUGNAc

1145878-98-3sc-489532
sc-489532A
0.5 mg
5 mg
$679.00
$5304.00
(0)

Galacto-PUGNAc, a hexose-derived acid halide, features a highly reactive carbonyl moiety that engages in selective nucleophilic attacks, particularly with hydroxyl groups. This compound's unique stereochemistry enhances its ability to form cyclic intermediates, influencing reaction dynamics. The halogen substituents not only increase electrophilicity but also modulate steric hindrance, allowing for tailored reactivity in complex synthetic routes. Its solubility characteristics further facilitate interactions in various solvent systems.

Pyrimethamine

58-14-0sc-208190
sc-208190A
sc-208190B
1 g
5 g
25 g
$80.00
$238.00
$825.00
5
(0)

Dihydrofolate reductase inhibitor; can indirectly affect HEXB by altering cellular metabolism and lysosomal function.

Conduritol B Epoxide (CBE)

6090-95-5sc-201356
sc-201356A
sc-201356B
sc-201356C
sc-201356D
sc-201356E
sc-201356F
5 mg
25 mg
50 mg
100 mg
250 mg
1 g
5 g
$79.00
$320.00
$500.00
$614.00
$1311.00
$5212.00
$20818.00
12
(1)

Inhibitor of beta-glucosidase; can potentially influence HEXB by affecting related glycosidase activities.

Nojirimycin-1-Sulfonic Acid

114417-84-4sc-208102
10 mg
$420.00
(0)

Glycosidase inhibitor; might indirectly affect HEXB by inhibiting related glycosidases.

Castanospermine

79831-76-8sc-201358
sc-201358A
100 mg
500 mg
$184.00
$632.00
10
(1)

Glycosidase inhibitor; can affect HEXB indirectly by modulating glycosidase activities.

Swainsonine

72741-87-8sc-201362
sc-201362C
sc-201362A
sc-201362D
sc-201362B
1 mg
2 mg
5 mg
10 mg
25 mg
$138.00
$251.00
$631.00
$815.00
$1832.00
6
(1)

Inhibitor of alpha-mannosidase; potentially influences HEXB by affecting glycoside processing pathways.

Deoxynojirimycin

19130-96-2sc-201369
sc-201369A
1 mg
5 mg
$73.00
$145.00
(0)

Alpha-mannosidase inhibitor; might impact HEXB indirectly by influencing glycoprotein processing.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Tyrosine kinase inhibitor; can indirectly affect HEXB by modulating cell signaling pathways.

Cyclophosphamide

50-18-0sc-361165
sc-361165A
sc-361165B
sc-361165C
50 mg
100 mg
500 mg
1 g
$90.00
$146.00
$469.00
$791.00
18
(1)

Alkylating agent; potentially affects HEXB through broader impacts on cellular metabolism and stress responses.