HELIC2 Activators
The chemical class of HELIC2 activators encompasses a range of small molecules and ions that interact with the protein directly or modulate its activity through influence on cellular or biochemical pathways. These activators can be broadly categorized based on their role in cellular metabolism, co-factor provision, stabilization of protein structure, modulation of protein-protein or protein-DNA interactions, as well as their function as agents that can affect the redox state or the ionic environment surrounding the protein.
ATP serves a pivotal role in the catalytic cycle of HELIC2 by providing the necessary energy for its helicase activity. Metal ions like zinc and magnesium are vital for the structural integrity of the protein and the catalytic process, given their role in stabilizing the conformation of HELIC2 and the ATP molecule. Similarly, salts such as sodium chloride and potassium chloride may affect the electrostatic interactions between the protein and its substrates. Glycerol and agents like DTT and EDTA can maintain the protein in a reduced, chelated, and active state. Contrarily, urea and compounds like N-Ethylmaleimide can modulate the activity by influencing the protein's three-dimensional structure. These molecules, although not directly interacting with the protein's active site, have a significant impact on the functional state of HELIC2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
Adenosine triphosphate (ATP) is the primary energy carrier in cells and is vital for many biological processes. HELIC2, being a helicase, requires energy for its unwinding activity. The binding and hydrolysis of ATP by HELIC2 are essential for its catalytic action, leading to the functional activation of the protein. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
Potassium ions play a role in maintaining cellular osmolarity and can affect enzyme activity. Potassium may affect the conformational state of HELIC2, which could modulate its activity. | ||||||
Glycerol | 56-81-5 | sc-29095A sc-29095 | 100 ml 1 L | $56.00 $153.00 | 12 | |
Used as a stabilizing agent in protein purifications, glycerol may stabilize the HELIC2 protein structure, possibly enhancing its activity by maintaining its proper conformation. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
While commonly known as a DNA intercalating agent, ethidium bromide may indirectly affect DNA-helicase interactions, potentially influencing the activity of helicases like HELIC2. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
This compound can modify cysteine residues and potentially influence the structure and function of proteins. It might modulate HELIC2 activity based on its cysteine reactivity. | ||||||
Urea | 57-13-6 | sc-29114 sc-29114A sc-29114B | 1 kg 2 kg 5 kg | $31.00 $43.00 $78.00 | 17 | |
At low concentrations, urea can sometimes act as a protein stabilizer, potentially enhancing the activity of helicases like HELIC2 by maintaining protein solubility. | ||||||