HDAC6 Inhibitors
Santa Cruz Biotechnology now offers a broad range of HDAC6 Inhibitors. Histone deacetylase proteins (HDACs) are a class of enzymes that remove acetyl groups (O=C-CH3) from an <ε>-N-acetyl lysine amino acid on a histone, allowing histones to wrap DNA more tightly. The deacetylation of histones is associated with transcriptional silencing. Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptic. HDIs are studied as a treatment for neurodegenerative diseases and have a potential for cancer therapy. HDAC6 Inhibitors offered by Santa Cruz inhibit HDAC6 and, in some cases, other chromatin remodeling and transcription regulation related proteins. View detailed HDAC6 Inhibitor specifications, including HDAC6 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 11 to 20 of 21 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KD 5170 | 940943-37-3 | sc-362755 | 10 mg | $398.00 | ||
KD 5170 functions as a selective HDAC6 inhibitor, distinguished by its unique interaction with the enzyme's catalytic domain. It engages in specific hydrophobic and electrostatic interactions, enhancing its binding stability. The compound demonstrates a notable ability to alter the acetylation status of target proteins, influencing cellular processes. Its reaction kinetics reveal a competitive inhibition profile, allowing for fine-tuned regulation of protein homeostasis and cellular dynamics. | ||||||
M 344 | 251456-60-7 | sc-203124 sc-203124A | 1 mg 5 mg | $107.00 $316.00 | 8 | |
M 344 acts as a selective inhibitor of HDAC6, characterized by its unique binding affinity to the enzyme's active site. This compound exhibits distinct molecular interactions, including hydrogen bonding and van der Waals forces, which contribute to its stability and specificity. Its kinetic profile indicates a non-competitive inhibition mechanism, allowing it to modulate histone acetylation levels effectively. Additionally, M 344 influences various cellular signaling pathways, showcasing its multifaceted role in cellular regulation. | ||||||
BATCP | 787549-23-9 | sc-252405 | 2 mg | $109.00 | ||
BATCP serves as a selective inhibitor of HDAC6, distinguished by its unique structural conformation that facilitates specific interactions with the enzyme's catalytic domain. This compound engages in hydrophobic interactions and electrostatic attractions, enhancing its binding efficacy. Its reaction kinetics reveal a reversible inhibition pattern, allowing for dynamic modulation of histone acetylation. Furthermore, BATCP's influence on protein-protein interactions underscores its role in cellular homeostasis and regulatory networks. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is an HDAC inhibitor that may target HDAC6 among other HDACs. | ||||||
PCI-24781 | 783355-60-2 | sc-364565 sc-364565A | 5 mg 50 mg | $182.00 $1330.00 | 1 | |
PCI-24781 is a selective HDAC6 inhibitor characterized by its ability to disrupt the enzyme's active site through specific hydrogen bonding and hydrophobic contacts. This compound exhibits a unique binding affinity that alters the conformational dynamics of HDAC6, influencing its enzymatic activity. The kinetics of PCI-24781 reveal a competitive inhibition mechanism, allowing for precise modulation of acetylation states in target proteins, thereby impacting cellular signaling pathways and protein stability. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat is a pan-HDAC inhibitor and may inhibit HDAC6 activity or expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 primarily targets class I HDACs but may have effects on HDAC6 as well. | ||||||
Nexturastat A | 1403783-31-2 | sc-478176 | 1 mg | $330.00 | ||
Nexturastat A is a selective HDAC6 inhibitor, down-regulating its activity. | ||||||
ACY-1215 | 1316214-52-4 | sc-507455 | 25 mg | $110.00 | ||
ACY-241 is an HDAC6-selective inhibitor, specifically targeting HDAC6. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $97.00 $525.00 | 1 | |
CI 994 is an HDAC inhibitor which might have effects on HDAC6. | ||||||