KD 5170 CAS: 940943-37-3
MF: C20H25N3O5S2
MW: 451.56
An HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6 inhibitor.

KD 5170 (CAS 940943-37-3)

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备用名: S-[2-[6-[[[4-[3-(Dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl]ethanethioc acid ester
应用; KD 5170 is an HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6 inhibitor
CAS号码: 940943-37-3
纯度: ≥95%
分子量: 451.56
分子式: C20H25N3O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

KD 5170 is an inhibitor of HDAC6 (IC50 = 0.014 μM), HDAC1 (IC50 = 0.020 μM), HDAC4 (IC50 = 0.026 μM), HDAC3 (IC50 = 0.075 μM), and HDAC2 (IC50 = 2.0 μM). KD 51570 exhibits broad spectrum inhibition of HDAC classes I and II in assays using purified recombinant human isoforms.

物理状态 :
Solid
溶解度 :
Soluble in 1eq. HCl (100 mM), and DMSO (100 mM).
保存 :
Store at -20° C
沸点 :
~637.9° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.60 (Predicted)
IC50 :
HDAC6: IC50 = 14 nM; HDAC1: IC50 = 20 nM; HDAC4: IC50 = 26 nM; HDAC3: IC50 = 75 nM; HDAC2: IC50 = 2.0 µM
pK值 :
pKa: 5.35 (Predicted), pKb: 9.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
17754557
MDL 号码 :
MFCD19690928
SMILES :
CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C

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