HAS2 Activators

Common HAS2 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Resveratrol CAS 501-36-0, β-Estradiol CAS 50-28-2, Dexamethasone CAS 50-02-2 and Curcumin CAS 458-37-7.

HAS2 activators are compounds that stimulate the enzymatic activity of HAS2 (hyaluronan synthase 2). HAS2 is one of the three isoforms of hyaluronan synthases, enzymes responsible for the synthesis of hyaluronan, a large non-sulfated glycosaminoglycan. Hyaluronan, often referred to as hyaluronic acid, is a crucial component of the extracellular matrix in many tissues, imparting structural integrity, hydration, and facilitating cell-cell interactions. It consists of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine, and its unique molecular structure allows it to retain water, providing tissues with resilience and pliability.

HAS2 is particularly notable for its role in producing high molecular weight hyaluronan, which is often associated with tissue homeostasis and beneficial cellular functions. In contrast, low molecular weight hyaluronan, resulting from the degradation of high molecular weight hyaluronan, can be involved in various signaling pathways, influencing processes such as cell migration and proliferation. The regulation of HAS2 activity, therefore, directly impacts the balance between these two forms of hyaluronan in tissues. HAS2 activators, by boosting the enzyme's activity, can potentially promote the synthesis of high molecular weight hyaluronan. Given the significance of hyaluronan in tissue biology, understanding the mechanisms by which HAS2 activators function and the subsequent alterations in hyaluronan dynamics offers valuable insights into cellular behavior, tissue biomechanics, and the intricate balance of the extracellular matrix components in various physiological contexts.