GTF2IRD2 Activators
GTF2IRD2 Activators comprise a diverse set of chemical compounds that indirectly enhance the functional activity of GTF2IRD2 through various biochemical pathways. Forskolin and Isoproterenol both raise intracellular cAMP levels, which leads to the activation of protein kinase A (PKA). PKA then enhances GTF2IRD2's transcriptional regulatory functions through phosphorylation. Similarly, dibutyryl cAMP, a membrane-permeable analog of cAMP, also activates PKA, resulting in the potential enhancement of GTF2IRD2 activity. The modulation of intracellular calcium levels by the ionophores Ionomycin and A23187 activate calcium-dependent signaling pathways, which can contribute to the facilitation of GTF2IRD2's role in gene regulation. Epigallocatechin gallate (EGCG) and Phorbol 12-myristate 13-acetate (PMA) work through the inhibition of protein kinases and activation of PKC, respectively, which could lead to a phosphorylation state that favors GTF2IRD2 functional activity.
Sphingosine-1-phosphate activates G protein-coupled receptors, influencing downstream signaling pathways, such as PKC, which may affect GTF2IRD2 activity. Retinoic acid alters gene expression profiles, potentially increasing GTF2IRD2 activity by affecting the transcriptional machinery to which GTF2IRD2 binds. Lithium chloride's inhibition of GSK-3 may lead to theenhanced activity of signaling pathways that contribute to the functional potency of GTF2IRD2. Finally, Sodium butyrate, as a histone deacetylase inhibitor, can lead to an increased acetylation state of histones, which is associated with a more open chromatin structure and could therefore enhance the accessibility of GTF2IRD2 to its DNA binding sites, improving its regulatory impact on transcription.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP activates PKA, which enhances GTF2IRD2 activity by phosphorylation, thus increasing its transcriptional regulatory functions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, which could lead to a reduction in competitive phosphorylation, indirectly promoting the phosphorylation state favorable to GTF2IRD2 functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways thus facilitating GTF2IRD2's role in transcription regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate various substrates and might enhance GTF2IRD2's activity indirectly through serine/threonine phosphorylation pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that raises cAMP levels, similarly to forskolin, thus potentially enhancing GTF2IRD2 activity via PKA-mediated phosphorylation pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels, contributing to the activation of calcium-dependent kinases that could facilitate GTF2IRD2's role in gene regulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate G protein-coupled receptors which influence downstream signaling pathways, such as PKC, potentially affecting GTF2IRD2 activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
cAMP directly activates PKA which can phosphorylate transcription factors and coactivators, potentially increasing GTF2IRD2's transcriptional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA, thus could enhance GTF2IRD2's activity by phosphorylation of associated transcriptional machinery. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences gene expression and could indirectly enhance GTF2IRD2 activity by affecting the transcription machinery or coactivators that associate with GTF2IRD2. | ||||||