GSS Activators
The chemical class termed GSS Activators encompasses a range of compounds that are hypothesized to indirectly influence the GSS protein and its associated pathways. These compounds primarily operate by modulating the cellular redox state and the demand for glutathione, a critical antioxidant in cellular defense mechanisms. Compounds like N-acetylcysteine, Alpha-lipoic acid, and S-adenosylmethionine play roles in enhancing the availability of substrates or co-factors necessary for glutathione synthesis, potentially increasing GSS activity. N-acetylcysteine, as a cysteine precursor, directly contributes to the increased availability of a key substrate for GSS. Alpha-lipoic acid and S-adenosylmethionine, through their roles in cellular metabolism and methylation processes, respectively, can influence the intracellular environment in a way that may enhance GSS activity.
Antioxidants such as Vitamin C, Vitamin E, and compounds like Butylated hydroxyanisole and Selenium, affect the oxidative stress response in cells. By altering the oxidative state, these compounds can indirectly increase the demand for glutathione, potentially enhancing GSS activity. This response is crucial in maintaining cellular redox balance and protecting against oxidative damage. Moreover, dietary compounds like Sulforaphane, Curcumin, and Resveratrol, known for their roles in modulating antioxidant defenses, provide insight into how GSS activity could be indirectly influenced. Their ability to upregulate antioxidant response elements and modulate signaling pathways related to oxidative stress can increase the cellular demand for glutathione synthesis, thereby potentially enhancing GSS activity. Additionally, the supplementation of micronutrients like Zinc and essential amino acids like Methionine can influence the antioxidative capacity of cells. Zinc plays a key role in various enzymatic processes and maintaining antioxidative status, while Methionine contributes to the synthesis of sulfur-containing compounds, including glutathione.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
Acts as a precursor to cysteine, which is a substrate for glutathione synthesis. By increasing cysteine availability, NAC could indirectly enhance GSS activity in the synthesis of glutathione. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Known to increase cellular glutathione levels. It could potentially enhance GSS activity indirectly by modulating the intracellular environment and increasing the demand for glutathione. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
Involved in methylation processes, SAMe can influence glutathione levels, potentially affecting GSS activity indirectly by altering the intracellular balance of sulfur-containing compounds. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $29.00 $96.00 | 1 | |
An antioxidant that can affect oxidative stress response pathways. By modulating oxidative stress, BHA could indirectly influence GSS activity as part of the cellular response to counteract oxidative damage. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
An essential micronutrient that plays a role in antioxidant defense mechanisms. Selenium supplementation could indirectly enhance GSS activity by modulating the antioxidative response in cells. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
An antioxidant that can regenerate glutathione from its oxidized form. By influencing glutathione turnover, Vitamin C could indirectly enhance GSS activity by increasing the cellular demand for glutathione synthesis. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
Acts as an antioxidant. Its role in protecting cells from oxidative stress could indirectly influence GSS activity by modulating the cellular redox state and glutathione levels. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc can influence various enzymes and is important for maintaining a healthy antioxidative status. Zinc supplementation could indirectly boost GSS activity by affecting the cellular antioxidative defense system. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
A compound found in cruciferous vegetables that can induce antioxidant response elements. Sulforaphane's ability to enhance antioxidant defenses could indirectly increase GSS activity by upregulating cellular antioxidant requirements. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known for its antioxidative properties, curcumin can modulate various signaling pathways related to oxidative stress. This modulation could indirectly influence GSS activity as part of the cellular response to maintain redox balance. | ||||||