GSDMC2 Inhibitors
GSDMC2 inhibitors belong to a specific category of chemical compounds designed to modulate the activity of the Gasdermin C2 (GSDMC2) protein. Gasdermin proteins have gained prominence in recent years due to their role in cell death and inflammation regulation. GSDMC2 is one of these proteins, and it plays a crucial role in cellular processes, although its exact functions are still being explored. The primary aim of GSDMC2 inhibitors is to interact with the GSDMC2 protein, thereby potentially influencing its activity and, consequently, impacting downstream cellular events.
These inhibitors are typically small molecules or chemical compounds engineered to selectively bind to GSDMC2, targeting either its active site or allosteric sites. This interaction can lead to the modulation of GSDMC2's behavior, potentially affecting its ability to form membrane pores, participate in cell death pathways, or perform other cellular functions. Researchers are primarily focused on deciphering the biological roles and mechanisms of GSDMC2 and how these inhibitors, by interacting with the protein, may shed light on various cellular processes. The development of GSDMC2 inhibitors remains an active area of research in the field of molecular pharmacology and biochemistry, contributing to a deeper understanding of cell biology and the functions of Gasdermin family proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomains, potentially downregulating transcription of inflammatory genes that might interact with or regulate gasdermin expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can alkylate cysteine residues in proteins and may modify proteins regulating gasdermin expression, though its activity is broad and not specific. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 inhibits NF-κB activation, potentially decreasing the transcription of genes involved in inflammation that could indirectly affect gasdermin levels. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NF-κB and may also affect the stability of mRNA, which could reduce the levels of proteins involved in inflammatory responses. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits proteasomes, potentially increasing the levels of regulatory proteins that suppress pro-inflammatory gene expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and may decrease the expression of inflammatory proteins that regulate gasdermins, though it has broad activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which may reduce transcriptional activation of genes involved in cell death processes associated with gasdermins. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK is a pan-caspase inhibitor that could indirectly inhibit gasdermin activation by preventing the cleavage of gasdermins by inflammatory caspases. | ||||||
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $92.00 $336.00 | 97 | |
Necrostatin-1 inhibits RIPK1, a kinase involved in necroptosis, which might be upstream of gasdermin activation in certain contexts. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $115.00 | 12 | |
QNZ is an NF-κB inhibitor and may thus reduce the expression of proteins involved in inflammation, potentially affecting gasdermin proteins. | ||||||