group II sPLA2 Activators
Chemicals classified as Group II sPLA2 Activators typically influence the enzyme's activity by modulating the levels of intracellular calcium, which is a key regulator of sPLA2, or by affecting the enzyme's interaction with its substrate, the cell membrane. Melittin, for instance, exerts its effects by disrupting cell membranes and elevating intracellular calcium levels, thus promoting the association of sPLA2 with its substrate. Similarly, A23187 (Calcimycin) and other calcium ionophores increase intracellular calcium, a crucial cofactor for sPLA2 activation.
On the other hand, compounds like PMA function through the activation of PKC, which can phosphorylate sPLA2, leading to its enhanced activity. In the context of lipid mediators, molecules like PAF, LPC, and S1P serve as allosteric modulators or participate in signaling cascades that upregulate sPLA2 activity. Furthermore, the inhibition of other phospholipases, such as with MAFP for cPLA2 and BEL for iPLA2, can result in the compensatory activation of sPLA2, reflecting the complex regulation of lipid signaling pathways in cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Melittin | 37231-28-0 | sc-200868 sc-200868A sc-200868B | 500 µg 1 mg 10 mg | $196.00 $339.00 $787.00 | 2 | |
This peptide increases the concentration of intracellular calcium, which can activate sPLA2 by enhancing the enzyme's association with membrane phospholipids. | ||||||
MAFP | 188404-10-6 | sc-203440 | 5 mg | $219.00 | 4 | |
This irreversible inhibitor of cPLA2 can upregulate sPLA2 activity by disrupting cellular homeostasis of arachidonic acid. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A potent activator of protein kinase C (PKC), which in turn can phosphorylate and activate sPLA2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
An ionophore that raises intracellular calcium levels, subsequently activating calcium-dependent sPLA2 isoforms. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
As a substrate for P2X and P2Y receptors, ATP can increase intracellular calcium concentrations, promoting sPLA2 activation. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
Through its receptor, PAF can activate intracellular signaling cascades that enhance sPLA2 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate sPLA2 through G protein-coupled receptor signaling pathways. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
The substrate and product of sPLA2 activity, excess arachidonic acid can serve as a feedback activator of the enzyme. | ||||||