GPR45 Activators
GPR45, a member of the G protein-coupled receptor (GPCR) family, represents a fascinating area of study within molecular biology. GPCRs are known for their diverse roles in cellular communication, responding to a variety of external signals to initiate internal cellular responses. GPR45, like its GPCR relatives, spans the cell membrane and is involved in transducing extracellular signals into cellular actions. The expression of GPR45, which refers to the process by which the GPR45 gene is transcribed and translated into the functional receptor protein, can be influenced by various biochemical factors. Understanding the regulation of GPR45 expression is crucial, as it can provide insights into the complex network of cellular signaling and the body's dynamic response to environmental changes.
Research into the regulation of GPR45 expression has identified a number of chemical compounds that could potentially serve as activators, each interacting with cellular mechanisms to upregulate the receptor's presence within cells. Compounds like forskolin, known to increase intracellular cAMP levels, could lead to the stimulation of GPR45 expression through cAMP-responsive elements within the gene's promoter region. Similarly, cholesterol, an essential component of cell membranes, might influence the expression of GPR45 by altering the membrane environment and receptor localization. Other compounds, such as retinoic acid and vitamin D3, are thought to be capable of binding to their respective nuclear receptors, potentially activating gene transcription pathways that include GPR45. Even dietary components like curcumin and sodium butyrate may play a role; curcumin, through its action on transcription factors like NF-κB, and sodium butyrate through epigenetic mechanisms involving histone deacetylase inhibition, could both create a biological context favorable for the upregulation of GPR45. These insights into the regulation of GPR45 by such diverse molecules add to our understanding of the intricate web of cellular signaling and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may directly stimulate the expression of GPR45 by activating adenylate cyclase, leading to a surge in cAMP, which can initiate a cascade that culminates in the transcription of the GPR45 gene. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol could upregulate GPR45 expression through engagement with beta-adrenergic receptors, triggering a signaling pathway that results in the elevation of transcription factors specific to the GPR45 gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may induce GPR45 expression by binding to its nuclear receptors, which can dimerize and bind to retinoic acid response elements upstream of the GPR45 gene, initiating transcription. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Cholesterol may upregulate GPR45 by embedding within the lipid rafts of the cellular membrane, potentially enhancing the assembly and function of GPR45 receptor complexes. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol could induce GPR45 expression by activating vitamin D receptors that interact with promoter regions of the GPR45 gene, thereby stimulating its transcription. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 might stimulate GPR45 expression by binding to E-prostanoid receptors, which could lead to the activation of transcription factors that increase the GPR45 gene expression. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin could upregulate GPR45 by triggering sensory neurons that respond by increasing the expression of GPR45 as part of a neuronal adaptive response mechanism. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol may stimulate the transcription of GPR45 by engaging estrogen receptors that then bind to estrogen response elements in the GPR45 gene promoter region, enhancing its transcriptional activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone could upregulate GPR45 by activating the transcription factor PPAR-gamma, which might then bind to PPAR response elements within the GPR45 gene promoter, increasing gene transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium may induce GPR45 expression by inhibiting GSK-3β, which could lead to the activation of transcriptional activators that enhance the transcription of the GPR45 gene. | ||||||