Gm98 Activators
Myelin regulatory factor (Myrf) activators encompass a range of chemicals that can indirectly enhance the functional activity of Myrf through specific signaling pathways or biological processes. The mechanisms by which these chemicals operate are diverse yet interconnected, involving a variety of intracellular signaling cascades. Compounds such as cAMP and its analogs like Forskolin and Dibutyryl cAMP, elevate intracellular cAMP levels, leading to the activation of PKA. Activated PKA can phosphorylate transcription factors, potentially augmenting Myrf's role in the expression of myelin-specific genes. Similarly, Lithium chloride's influence on the phosphoinositide pathway and subsequent modulation of GSK-3β activity can enhance Myrf's function by indirectly affecting the regulation of transcription factors that control myelin gene expression.
Other molecules, like Retinoic Acid, Sphingosine-1-phosphate, and Ionomycin, engage with distinct receptor-mediated pathways that converge on the regulation of gene expression related to myelination. Retinoic acid, for example, interacts with nuclear receptors that may enhance Myrf's transcriptional activity, while Sphingosine-1-phosphate signaling can orchestrate the nuclear events that support Myrf's role in oligodendrocyte differentiation. Ionomycin's elevation of intracellular calcium levels can trigger calcium-dependent signaling mechanisms, potentially enhancing Myrf's involvement in the formation of the myelin sheath.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
cAMP serves as a secondary messenger known to activate protein kinase A (PKA). PKA can then phosphorylate various transcription factors, potentially enhancing Myrf's function in promoting myelin gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. This could enhance the phosphorylation of transcription factors involved with Myrf's function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts on retinoic acid receptors, which can form heterodimers with other transcription factors and bind to DNA, potentially enhancing Myrf-mediated transcription. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule activates S1P receptors, which can lead to downstream effects on nuclear receptors that may augment Myrf's activity in oligodendrocyte differentiation and myelination. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea can increase the expression of genes related to cell cycle arrest and differentiation, possibly supporting Myrf's role in oligodendrocyte maturation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which may influence transcription factors and enhance the activity of Myrf in myelin gene expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin raises intracellular calcium levels, which can activate calcium-dependent signaling pathways, potentially enhancing Myrf function in myelin sheath formation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a membrane-permeable cAMP analog that activates PKA, potentially enhancing Myrf's role in myelin-related gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences the phosphoinositide pathway and can impact GSK-3β activity, which in turn can enhance Myrf's function in myelin gene expression through transcription factor regulation. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
K252a is a kinase inhibitor that might enhance Myrf's function by affecting various signaling pathways that regulate transcription factors and myelin gene expression. | ||||||