Gm498 Activators
Acte1 Activators are a category of small molecules known for their ability to modulate the polymerization dynamics of actin, a globular multi-functional protein that forms microfilaments. These activators exert their influence on actin's behavior at the cellular level, which is critical for various aspects of cellular function, including maintenance of cell shape, motility, and intracellular transport. The actin monomer, also known as G-actin, polymerizes to form filamentous actin (F-actin), which is an integral component of the cytoskeleton. Acte1 Activators work by stabilizing or promoting the formation of F-actin from monomeric G-actin units, thereby affecting the balance between these two forms. Some of these molecules, such as phalloidin, bind to F-actin and lock it in a polymerized state, preventing depolymerization and thus stabilizing the actin filaments. Others like jasplakinolide enhance the polymerization rate by nucleating actin assembly, leading to an increase in the overall amount of F-actin. These molecules are important tools for studying the behavior of actin within cells and can reveal much about the underlying principles of cellular architecture and movement.
Acte1 Activators also include agents that indirectly influence actin polymerization by sequestering actin monomers or affecting the dynamics of filamentous actin. For example, latrunculin A binds to actin monomers and prevents their polymerization, ultimately leading to a depletion of cellular F-actin and an increase in the pool of G-actin. This can result in a compensatory enhancement of actin filament formation as the cell attempts to restore the equilibrium. Cytochalasins, on the other hand, cap the growing ends of actin filaments, thereby halting elongation but also leading to an accumulation of free G-actin monomers which can drive the formation of new filaments.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can enhance actin polymerization. This action directly increases the amount of filamentous actin (F-actin), leading to the enhanced functional activity of actin, epsilon 1 by increasing its incorporation into actin filaments. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Phalloidin binds specifically and stabilizes F-actin, preventing its depolymerization. This binding increases the stability of actin filaments, enhancing the functional activity of actin, epsilon 1 by maintaining its assembly into filaments. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, preventing further polymerization and leading to filament stabilization. This can result in an increased concentration of monomeric actin, epsilon 1, which is then available to form new actin filaments. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers and sequesters them, thereby indirectly promoting the formation of new actin filaments. The increase in monomeric actin pool can enhance the activity of actin, epsilon 1 as it becomes incorporated into new filaments. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and binds to actin dimers, which leads to an increased pool of actin monomers. This can enhance the functional activity of actin, epsilon 1 by promoting its incorporation into new filaments. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium chloride is essential for the polymerization of actin filaments. It can enhance the functional activity of actin, epsilon 1 by facilitating its incorporation into the growing filaments due to its role in stabilizing the structure of actin-ATP complexes. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule dynamics, which can lead to a compensatory increase in actin polymerization, indirectly enhancing the functional activity of actin, epsilon 1 by increasing its incorporation into actin filaments as part of the cytoskeletal remodeling. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and can indirectly influence actin filament dynamics. This may enhance the functional activity of actin, epsilon 1 as cells often coordinate the remodeling of actin filaments in response to changes in microtubule stability. | ||||||