Glut12 Activators
Glut12 activators constitute a group of chemical agents designed to enhance the function of the Glucose transporter type 12 (Glut12), a protein involved in the facilitated transport of glucose across cell membranes. As a member of the glucose transporter family, Glut12 enables the passage of glucose into cells, utilizing the concentration gradient of glucose without the direct expenditure of ATP. Unlike inhibitors, activators of Glut12 work by increasing the transporter's affinity for glucose or by promoting a conformational change that leads to a higher rate of glucose transport. These compounds may interact with the transporter directly at the glucose binding site, or they may bind to allosteric sites to induce an effect that increases the overall transport activity. The heightened activity of Glut12 resulting from such activation could lead to an increased uptake of glucose in cells where Glut12 is expressed, thereby affecting the glucose distribution and its availability within various tissues.
The discovery and optimization of Glut12 activators involve a thorough understanding of the transporter's structure and glucose transport mechanism. Researchers typically embark on this by mapping the Glut12 protein's structure through various techniques such as X-ray crystallography, cryo-electron microscopy, or computational modeling. Knowledge of the structural features of Glut12 allows for the identification of potential activator binding sites and the rational design of small molecules that could modulate the transporter's activity. The development process includes synthesizing various chemical compounds and evaluating their capacity to interact with and activate Glut12. These evaluations often involve in vitro assays using cell lines that express Glut12, measuring the uptake of glucose analogs that can be detected following transport into the cells. Compounds that show promising activating effects on Glut12 are further refined to increase their potency, selectivity, and ability to engage with the transporter under physiological conditions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin, could hypothetically induce Glut12 expression as it is known to increase insulin sensitivity and glucose uptake in cells. Its potential effect on Glut12 could be related to its overall role in enhancing glucose transport into cells. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a thiazolidinedione, enhances insulin sensitivity in peripheral tissues. It could hypothetically induce Glut12 expression as a mechanism to increase glucose transport into cells, contributing to its overall effect on glucose metabolism. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone, another thiazolidinedione, acts as a PPARγ agonist and is known for improving insulin sensitivity. Hypothetically, to enhance its role in glucose metabolism, it might increase Glut12 expression, thus facilitating greater glucose transport into cells. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cyclic AMP levels, a secondary messenger in many cell signaling pathways. This could hypothetically upregulate Glut12 expression as a downstream effect, thus promoting glucose uptake into cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate is a key active compound in green tea and has been shown to positively affect insulin sensitivity and glucose uptake. It could potentially induce Glut12 expression to facilitate these effects, though the exact mechanism would need further investigation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes, has been associated with improved insulin sensitivity and glucose uptake. Hypothetically, as part of its metabolic effects, it might stimulate Glut12 expression to facilitate glucose transport into cells. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Lipoic acid, also known as alpha-lipoic acid, has been shown to improve insulin sensitivity and glucose metabolism. It could potentially stimulate Glut12 expression as a mechanism to enhance glucose uptake into cells, although this would need to be confirmed through further research. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $46.00 $68.00 | 1 | |
Chlorogenic acid, a major phenolic compound found in coffee, has been shown to affect glucose metabolism. Hypothetically, it could stimulate Glut12 expression as part of its action on enhancing glucose uptake, but this would need to be confirmed through further research. | ||||||