Date published: 2026-1-9

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GlcNAc kinase Inhibitors

GlcNAc kinase inhibitors represent a class of chemical compounds designed to modulate the activity of GlcNAc kinase, a crucial enzyme involved in cellular glycosylation processes. Glycosylation, the addition of sugar moieties to proteins and lipids, plays a pivotal role in various cellular functions, including signal transduction, protein stability, and cell adhesion. GlcNAc kinase is an essential player in this intricate biochemical pathway as it catalyzes the phosphorylation of N-acetylglucosamine (GlcNAc), a critical sugar molecule involved in glycosylation. Inhibitors within this chemical class target GlcNAc kinase with the aim of disrupting its enzymatic activity, which subsequently influences glycosylation events within the cell. The mechanism of action of GlcNAc kinase inhibitors typically involves binding to the enzyme's active site, thereby obstructing its ability to phosphorylate GlcNAc. By interfering with this phosphorylation process, these inhibitors perturb the initiation and progression of glycosylation pathways. This, in turn, can have widespread repercussions on cellular processes, as glycosylation is implicated in numerous essential functions, such as protein folding, cell signaling, and immune response regulation. The chemical diversity within this class of inhibitors allows for the exploration of various structural and functional relationships, enabling researchers to better understand the intricacies of glycosylation and its role in cellular biology.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

3-O-Methyl-N-acetyl-D-glucosamine

94825-74-8sc-202886A
sc-202886
sc-202886B
1 mg
5 mg
10 mg
$102.00
$245.00
$388.00
2
(1)

3-O-Methyl-N-acetyl-D-glucosamine is a notable substrate for GlcNAc kinase, characterized by its ability to undergo phosphorylation, which is crucial for glycosylation processes. Its structural features facilitate specific enzyme-substrate interactions, enhancing reaction specificity and kinetics. The compound's unique methyl and acetyl groups influence its solubility and reactivity, allowing it to participate in diverse metabolic pathways and cellular signaling mechanisms.

Acetazolamide

59-66-5sc-214461
sc-214461A
sc-214461B
sc-214461C
sc-214461D
sc-214461E
sc-214461F
10 g
25 g
100 g
250 g
500 g
1 kg
2 kg
$81.00
$177.00
$434.00
$541.00
$883.00
$1479.00
$2244.00
1
(1)

Acetazolamide inhibits GlcNAc kinase by interfering with the enzyme's catalytic activity, leading to reduced GlcNAc phosphorylation and glycosylation processes within cells.

BAY 61-3606

sc-507485
2 mg
$345.00
1
(0)

BAY 61-3606 inhibits GlcNAc kinase by competing with ATP for binding to the enzyme's active site, disrupting GlcNAc phosphorylation and glycosylation events.

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

105650-23-5sc-208996B
sc-208996C
sc-208996
sc-208996A
sc-208996D
sc-208996E
1 mg
5 mg
10 mg
25 mg
50 mg
100 mg
$118.00
$203.00
$322.00
$634.00
$1076.00
$1733.00
38
(2)

This compound acts as a GlcNAc kinase inhibitor by interacting with the enzyme′s active site, hindering the phosphorylation of GlcNAc, and disrupting glycosylation events within cells.

3-Bromo-7-nitroindazole

74209-34-0sc-200347
sc-200347A
5 mg
25 mg
$20.00
$26.00
1
(1)

3-Bromo-7-nitroindazole inhibits GlcNAc kinase through a mechanism that involves binding to the enzyme's active site, blocking GlcNAc phosphorylation, and impeding glycosylation pathways.

BRD 7389

376382-11-5sc-361129
sc-361129A
10 mg
50 mg
$181.00
$714.00
(0)

BRD7389 functions as a GlcNAc kinase inhibitor by binding to the enzyme's ATP-binding site, thereby inhibiting GlcNAc phosphorylation and interfering with glycosylation events in cells.

2-Amino-2-norbornanecarboxylic acid

20448-79-7sc-237901
100 mg
$182.00
1
(2)

BCH inhibits GlcNAc kinase by serving as a competitive inhibitor of the enzyme's substrate, GlcNAc. It hinders the phosphorylation of GlcNAc, leading to impaired glycosylation processes within cells.