GIPR Activators
The chemical group termed GIPR Activators consists of diverse molecules capable of directly or indirectly modulating the activity of the Gastric Inhibitory Polypeptide Receptor (GIPR). Many compounds in this group either influence intracellular cAMP levels or are associated with pathways that have crosstalk with GIPR. For instance, Forskolin, known for activating adenylyl cyclase, and IBMX, a phosphodiesterase inhibitor, both elevate cAMP levels, setting in motion downstream signaling events associated with GIPR. Similarly, the cAMP analog 8-Br-cAMP, PDBu, an activator of protein kinase C, and even Epinephrine, which stimulates adenylate cyclase via beta-adrenergic receptors, are all capable of influencing cellular mechanisms tied to GIPR.
While some compounds, such as GIP (1-42), have direct interactions with GIPR, others like Exendin-4 and Liraglutide, primarily linked with the GLP-1 receptor, exhibit interconnected pathways with GIPR and thus can have a consequential influence on its activity. Additionally, agents like SQ 22536 and H-89, which respectively inhibit adenylate cyclase and protein kinase A, underscore the intricacies of the signaling cascades related to GIPR.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can activate adenylyl cyclase, leading to increased cyclic AMP levels, which can indirectly activate GIPR through its downstream effects. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
An inhibitor of phosphodiesterase, IBMX can raise intracellular cAMP levels, indirectly stimulating pathways linked to GIPR. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $146.00 $198.00 | 1 | |
Although primarily a GLP-1 receptor agonist, Exendin-4 can have cross-reactivity with GIPR and can indirectly influence its activation. | ||||||
Liraglutide | 204656-20-2 | sc-507404 | 1 mg | $220.00 | ||
A GLP-1 receptor agonist that can indirectly affect GIPR due to the interconnected pathways between GLP-1 and GIP signaling. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
An activator of protein kinase C (PKC), which can influence intracellular signaling pathways that may indirectly modulate GIPR activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Can activate adenylate cyclase via beta-adrenergic receptors, potentially leading to an indirect activation of GIPR-associated pathways. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
An adenylate cyclase inhibitor, which through modulation of cAMP levels, can have an indirect influence on GIPR signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A phosphodiesterase inhibitor that can increase intracellular cAMP levels, thereby indirectly influencing GIPR-associated pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog which can activate protein kinase A and can indirectly influence pathways associated with GIPR. | ||||||