GGPS1 Activators
GGPS1 activators are chemical entities that increase the activity or expression of the enzyme geranylgeranyl diphosphate synthase 1 (GGPS1). This enzyme is a key player in the biosynthetic pathway that produces geranylgeranyl diphosphate (GGPP), which is essential for the post-translational modification of a variety of proteins through geranylgeranylation. This modification is crucial for the proper localization and function of these proteins within cellular membranes. GGPS1 activators may act by various biochemical mechanisms, such as upregulating the transcription of the GGPS1 gene, stabilizing GGPS1 mRNA, enhancing the translation of GGPS1 protein, or by directly interacting with the enzyme to increase its catalytic efficiency.
The regulation and activation of GGPS1 by these chemical compounds can have significant impacts on cellular metabolism, given the central role of GGPP in numerous biological processes. For instance, increasing the activity of GGPS1 can lead to elevated levels of GGPP, which in turn can affect the prenylation and function of small GTPases and other proteins involved in signaling pathways. GGPS1 activators can also interact with the broader isoprenoid synthesis and cholesterol metabolism pathways, which share precursors and regulatory mechanisms with the pathway in which GGPS1 is involved. These interactions might lead to adjustments in cellular metabolism to accommodate shifts in demand for isoprenoid products. Moreover, such activators can influence the cellular balance of isoprenoids and cholesterol, affecting various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, potentially causing a compensatory upregulation of GGPS1 to maintain isoprenoid synthesis. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Similar to lovastatin, simvastatin may cause an increase in GGPS1 expression by inhibiting the upstream enzyme in the mevalonate pathway. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $162.00 $474.00 | 14 | |
As a product of GGPS1 activity, geranylgeraniol could induce GGPS1 expression through a feedback loop mechanism. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $281.00 $374.00 | 2 | |
Farnesol serves as a precursor in the isoprenoid synthesis pathway and might induce GGPS1 expression to increase GGPP levels. | ||||||
Squalene | 111-02-4 | sc-281155 sc-281155A sc-281155B | 10 ml 100 ml 500 ml | $49.00 $92.00 $215.00 | 1 | |
Squalene, involved in cholesterol synthesis, might influence GGPS1 expression as part of the regulatory network of the mevalonate pathway. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression and might influence GGPS1 as part of a broader effect on cellular growth and differentiation. | ||||||