GCP3 Activators
GCP3 Activators encompass a broad category of compounds, predominantly microtubule stabilizers and destabilizers. The activators function by disrupting the depolymerization of microtubules. This results in the stabilization of gamma-tubulin complexes, including GCP3. Stabilized gamma-tubulin complexes can exhibit enhanced activity in microtubule nucleation, the primary function of GCP3. The increased stability provided by these compounds thus directly enhances the functional activity of GCP3.
GCP3 Activators work by binding to tubulin and inhibiting its polymerization into microtubules. This disruption in microtubule dynamics leads to an increase in the activity of gamma-tubulin complexes, including GCP3, in nucleating new microtubules. Despite their differing mechanisms of action, both stabilizers and destabilizers lead to the functional enhancement of GCP3. They do this by either directly stabilizing the GCP3-containing gamma-tubulin complex or indirectly promoting its activity by increasing the demand for new microtubule nucleation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Docetaxel is another microtubule stabilizer that inhibits microtubule disassembly. This results in the stabilization of gamma-tubulin complexes, including GCP3. The increased stability can lead to enhanced activity of GCP3 in microtubule nucleation. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine is a microtubule destabilizer that binds tubulin and inhibits its polymerization into microtubules. This disrupts microtubule dynamics, leading to an increase in the activity of gamma-tubulin complexes, including GCP3, in nucleating new microtubules. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B is a microtubule stabilizer that binds the tubulin with a higher affinity than Paclitaxel. This can lead to the stabilization of gamma-tubulin complexes, including GCP3, enhancing their activity in microtubule nucleation. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin is a microtubule destabilizer that binds tubulin and inhibits its polymerization into microtubules. This can enhance the activity of gamma-tubulin complexes, including GCP3, in nucleating new microtubules. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin is a microtubule dynamics inhibitor that binds to tubulin and inhibits its polymerization into microtubules. This can enhance the activity of gamma-tubulin complexes, including GCP3, in nucleating new microtubules. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine is a microtubule destabilizer that binds tubulin and inhibits its polymerization into microtubules. This can enhance the activity of gamma-tubulin complexes, including GCP3, in nucleating new microtubules. | ||||||