Gastrin Inhibitors
Gastrin is a peptide hormone primarily produced by G cells in the stomach and plays a crucial role in the regulation of gastric acid secretion and gastrointestinal motility. Upon release, gastrin binds to specific receptors on parietal cells in the stomach, leading to the activation of signaling pathways that stimulate the secretion of gastric acid. Additionally, gastrin promotes the growth and proliferation of gastric mucosal cells, contributing to the maintenance of gastric mucosal integrity. The hormone also acts as a trophic factor for enterochromaffin-like (ECL) cells, enhancing histamine release, which further stimulates acid secretion. Gastrin's involvement in these physiological processes underscores its significance in gastric function and homeostasis.
Inhibition of gastrin signaling pathways can be achieved through various mechanisms aimed at attenuating its effects on gastric acid secretion and cell proliferation. One approach involves targeting gastrin receptors on parietal cells, thereby impeding their activation by gastrin. Another strategy is to inhibit the synthesis or release of gastrin from G cells in the stomach, effectively reducing its availability for interaction with its receptors. Additionally, blocking downstream signaling pathways activated by gastrin, such as the protein kinase C (PKC) pathway, can impede its physiological effects. Modulating the activity of enzymes involved in gastric acid secretion, such as H+/K+-ATPase, can also contribute to inhibiting gastrin-mediated acid secretion. Overall, inhibiting gastrin function represents a strategy for conditions characterized by excessive gastric acid secretion or aberrant cell proliferation in the stomach.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $193.00 | ||
Ranitidine is an H2 receptor antagonist. It can inhibit the effect of gastrin by blocking histamine-activated gastric acid secretion. | ||||||
Pantoprazole | 102625-70-7 | sc-204830 sc-204830A | 100 mg 500 mg | $89.00 $255.00 | 2 | |
Pantoprazole is a proton pump inhibitor. It blocks the final step of gastric acid production, which is stimulated by gastrin. | ||||||
Famotidine | 76824-35-6 | sc-205691 sc-205691A | 500 mg 1 g | $65.00 $111.00 | ||
Famotidine, an H2 receptor antagonist, can inhibit the effects of gastrin by stopping histamine-stimulated gastric acid secretion. | ||||||
Roxatidine | 78273-80-0 | sc-280071A sc-280071 | 1 mg 10 mg | $61.00 $459.00 | 1 | |
Roxatidine is an H2 receptor antagonist. It prevents the effects of gastrin by inhibiting histamine-activated gastric acid secretion. | ||||||
Lansoprazole | 103577-45-3 | sc-203101 sc-203101A | 500 mg 1 g | $59.00 $176.00 | 6 | |
Lansoprazole is a proton pump inhibitor. It can inhibit the final step of gastric acid production, a process that gastrin stimulates. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole, a proton pump inhibitor, stops the final step of gastric acid production, which is stimulated by gastrin. | ||||||
Rabeprazole | 117976-89-3 | sc-204872 sc-204872A | 10 mg 25 mg | $349.00 $620.00 | 2 | |
Rabeprazole is a proton pump inhibitor. It can inhibit the final step of gastric acid production, a process that gastrin stimulates. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is an H2 receptor antagonist. It can inhibit the effects of gastrin by blocking histamine-activated gastric acid secretion. | ||||||
(R)-Lansoprazole | 138530-94-6 | sc-208242 | 1 mg | $240.00 | 2 | |
(R)-Lansoprazole is a proton pump inhibitor. It can inhibit the final step of gastric acid production, which is stimulated by gastrin. | ||||||