Gas2L3 Inhibitors
Chemical inhibitors of Gas2L3 can interfere with the protein's role in regulating the microtubule cytoskeleton, a crucial component of cell division and intracellular transport. Paclitaxel and Peloruside A stabilize microtubules, which restricts the dynamic changes necessary for Gas2L3 to perform its regulatory functions. Conversely, chemicals like Nocodazole, Colchicine, Vinblastine, Vincristine, Podophyllotoxin, Griseofulvin, Tubulysin A, Parbendazole, and Albendazole disrupt microtubule polymerization, a process essential for Gas2L3 to exercise its role in modulating the microtubule network. Nocodazole and Colchicine, in particular, bind to tubulin to prevent its assembly into microtubules, directly inhibiting Gas2L3's interaction with the microtubule structures. Vinblastine and Vincristine specifically target tubulin to halt microtubule assembly, which impedes Gas2L3's capacity to regulate the cytoskeleton and mitotic spindle.
Eribulin presents a unique mode of action by inhibiting only the growth phase of the microtubules without affecting shortening, which can specifically disrupt Gas2L3's role in microtubule elongation during cell division. Meanwhile, Griseofulvin binds to tubulin, blocking its polymerization and consequently the functional activity of Gas2L3 that depends on the structural integrity of microtubules. Tubulysin A's inhibition of tubulin polymerization leads to microtubule destabilization, which can hinder Gas2L3's associated functions with microtubule dynamics and structure. The actions of these chemical inhibitors collectively result in the impairment of Gas2L3's ability to regulate microtubule-based processes, such as cell division and cytoskeletal organization, by altering the stability and assembly of microtubule networks within cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which inhibits cell division. Gas2L3 is involved in the regulation of the microtubule cytoskeleton. By stabilizing microtubules, Paclitaxel can inhibit the function of Gas2L3, as Gas2L3 requires dynamic microtubules for its role in cell division and cytoskeletal regulation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. Gas2L3 plays a role in modulating the microtubule network; by preventing the polymerization of microtubules, Nocodazole can inhibit the ability of Gas2L3 to interact with and regulate microtubules. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules. Gas2L3's function is closely associated with microtubule dynamics; thus, the inhibition of microtubule polymerization by Colchicine directly inhibits the functional role of Gas2L3 in the cell. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. By halting microtubule assembly, Vinblastine impedes Gas2L3's ability to regulate the cytoskeleton and mitotic spindle, which is part of its functional role in the cell. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization into microtubules. The inhibition of microtubule assembly can impair Gas2L3's ability to regulate microtubule-based processes within the cell. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits microtubule growth without affecting microtubule shortening. By specifically inhibiting the growth phase of microtubules, Eribulin can inhibit Gas2L3's function, which relies on microtubule dynamics. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin and preventing its polymerization. This action can inhibit Gas2L3's function, which is dependent on the integrity and dynamics of microtubules. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole disrupts microtubule polymerization. By targeting microtubules, Albendazole can inhibit Gas2L3's functional role in the regulation of the microtubule cytoskeleton within the cell. | ||||||