GAMT Activators
The GAMT Activators represent a class of compounds selected for their to indirectly enhance the functional activity of GAMT, a crucial enzyme in creatine synthesis. This class includes direct substrates and cofactors of GAMT, such as S-Adenosylmethionine and its stable form SAMe, which provide the necessary methyl groups for GAMT's enzymatic reaction. Enhancing the availability of these methyl donors is a direct method to increase GAMT activity. Additionally, compounds like Betaine, Choline, Methionine, and Dimethylglycine, which are involved in methyl donor metabolism, could also support GAMT activity. Their roles in providing or influencing the availability of methyl groups could indirectly facilitate GAMT's function in creatine synthesis.
Furthermore, essential nutrients like Folic Acid and Vitamin B12, integral to one-carbon metabolism and methylation reactions, could indirectly enhance GAMT activity by ensuring efficient SAM synthesis. Arginine and Glycine, precursors in the biosynthesis of guanidinoacetate, the substrate for GAMT, could also indirectly influence GAMT activity by ensuring substrate availability. Additionally, the presence of Creatine, the end product of GAMT's reaction, might provide feedback regulation, influencing GAMT's expression and activity. Compounds like Ornithine, which are part of the urea cycle and arginine metabolism, demonstrate the interconnectedness of metabolic pathways and how they can influence enzymes like GAMT.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
As a methyl donor, it's directly involved in GAMT's catalytic process, potentially enhancing its activity by providing substrate availability. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Acts as a methyl donor in other pathways, could enhance GAMT activity by indirectly increasing methyl group availability. | ||||||
Choline base solution | 123-41-1 | sc-239545 | 100 ml | $79.00 | ||
A precursor of betaine, could indirectly support GAMT activity by contributing to the methyl donor pool through its metabolism to betaine. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Involved in one-carbon metabolism, essential for SAM synthesis; its availability could enhance GAMT activity by supporting methylation reactions. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Essential for SAM synthesis and methylation reactions; could indirectly enhance GAMT activity by supporting methyl donor availability. | ||||||
DL-Methionine | 59-51-8 | sc-397777 | 100 g | $45.00 | ||
A precursor of SAM, could enhance GAMT activity by increasing the availability of the primary methyl donor. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
A substrate for guanidinoacetate synthesis, its availability could indirectly influence GAMT activity by ensuring substrate availability. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
A precursor of guanidinoacetate, could indirectly enhance GAMT activity by increasing the availability of its substrate. | ||||||
Ornithine | 70-26-8 | sc-507552 | 100 mg | $77.00 | ||
Interacts with the urea cycle and arginine metabolism; could indirectly influence GAMT activity through metabolic interconnections. | ||||||